Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

05 April 2022: Original Paper

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

Okjoo Lee 1ABCDEF , Jinsoo Rhu 1ABCDE* , Gyu-Seong Choi 1ABCDE , Jong Man Kim 1CD , Kyunga Kim 2CD , Jae-Won Joh 1CD

DOI: 10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

Table 3 The risk factors of hepatocellular carcinoma recurrence analyzed by Cox proportional-hazards regression models.

Recipient characteristicsUnivariableMultivariable
HR95% CIP-valueHR95% CIP-valueHR95% CIP-value
Sex (Male)1.9680.959–4.0390.0651.3170.634–2.7390.4601.3210.635–2.7470.457
Age (≥60 years)0.7320.455–1.1750.196
MELD score (≥20 points)0.7980.372–1.7160.564
ABO-incompatible LT1.2580.767–2.0630.364
Regional treatment (≥3 times)2.3811.637–3.4611.7751.204–2.6160.0041.7841.210–2.6290.004
Tumor size (≥3 cm)2.3471.617–3.4061.5701.070–2.3040.0211.5611.065–2.2880.022
Tumor number (≥3)1.8771.285–2.7420.0011.2670.861–1.8640.2311.2720.863–1.8730.224
AFP (≥100 ng/dL)2.9232.013–4.2431.9121.293–2.8280.0011.9111.293–2.8250.001
Poor pathologic finding (Edmonson criteria ≥3)1.4510.842–2.5010.181
Microvascular invasion5.3733.394–8.5053.4082.085–5.5723.3792.067–5.523
Low GRWR (1.9751.000–3.9030.0501.3730.689–2.7360.3671.3790.692–2.7480.361
Statin user1.2770.510–3.1930.6020.9290.366–2.3570.877
* Statin user and, cDDD were considered as time dependent covariates.
MELD – model for end-stage liver disease; AFP – alpha-fetoprotein; GRWR – graft-recipient weight ratio; cDDD – cumulative defined daily dose.

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358