Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

05 April 2022: Original Paper

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

Okjoo Lee 1ABCDEF , Jinsoo Rhu 1ABCDE* , Gyu-Seong Choi 1ABCDE , Jong Man Kim 1CD , Kyunga Kim 2CD , Jae-Won Joh 1CD

DOI: 10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

Table 4 The risk factors of patient survival analyzed by Cox proportional-hazards regression models.

Recipient characteristicsUnivariableMultivariable
HR95% CIP-valueHR95% CIP-valueHR95% CIP-value
Sex (Male)1.5360.803–2.9390.194
Age (≥60 years)0.9890.639–1.5300.959
MELD score (≥20 points)1.1680.611–2.2340.638
ABO-incompatible LT0.8520.487–1.4900.574
Regional treatment (≥3 times)1.5011.042–2.1640.0291.2300.844–1.7920.2821.2680.870–1.8470.217
Tumor size (≥3 cm)1.5371.067–2.2120.0211.2290.842–1.7920.2851.1920.817–1.7410.362
Tumor number (≥3)1.3500.909–2.0030.137
AFP (≥100 ng/dL)2.0591.414–2.9971.5921.068–2.3720.0221.5971.072–2.3790.021
Poor pathologic finding (Edmonson criteria ≥3)1.5030.886–2.5490.131
Microvascular invasion2.3981.630–3.5291.9661.287–3.0020.0021.9081.250–2.9130.003
Low GRWR (1.6220.871–3.0190.127
Statin user0.4710.148–1.4980.2030.3880.121–1.2420.111
* Statin user and, cDDD were considered as time dependent covariates.
MELD – model for end-stage liver disease; AFP – alpha-fetoprotein; GRWR – graft-recipient weight ratio; cDDD – cumulative defined daily dose.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358