02 August 2022 : Original article
The Association Between Tacrolimus Levels and Hyperkalemia in Allograft Recipients Who Underwent Heart or Lung Transplantation in New Orleans, USA Between 2013 and 2019: A Single-Center Retrospective Study
Olivia L. Griffis
1ABCDEF*, Steven Q. Thai1ABCDEF, Cody Allison1ABCDEF, Brooke Baetz1ABCDEF, Alaa Mohammed23CE
DOI: 10.12659/AOT.935607
Ann Transplant 2022; 27:e935607
Table 3 Baseline characteristics of high-TAC (30-days post-transplant) vs low-TAC (300-days post-transplant).
| Total cohort (N=187) | High-TAC | Low-TAC | P value | |
|---|---|---|---|---|
| Age, years | 55.0 (40.0–61.0) | ---- | ---- | ---- |
| Female | 72 (38.5%) | ---- | ---- | ---- |
| African American | 43 (23.0%) | ---- | ---- | ---- |
| Heart transplant | 84 (44.9%) | ---- | ---- | ---- |
| Lung transplant | 103 (55.1%) | ---- | ---- | ---- |
| eGFR, mL/min/1.73 m | ---- | 71.7 (56.0–87.6) | 53.0 (41.6–67.5) | <0.0001 |
| Tacrolimus level, ng/mL | ---- | 11.3 (9.2–13.8) | 8.9 (7.3–10.5) | <0.0001 |
| Blood glucose level, mg/dL | ---- | 108.0 (93.0–137.0) | 101.0 (92.0–121.0) | 0.0011 |
| ACE/ARB | ---- | 28 (15.0%) | 52 (27.8%) | 0.0004 |
| Spironolactone/eplerenone | ---- | 0 (0%) | 1 (0.5%) | ---- |
| Insulin | ---- | 66 (35.3%) | 51 (27.3%) | 0.0039 |
| Loop/thiazide diuretic | ---- | 62 (33.2%) | 33 (17.7%) | <0.0001 |
| Potassium binder | ---- | 7 (3.7%) | 3 (1.6%) | 0.1573 |
| Potassium supplementation | ---- | 1 (0.5%) | 3 (1.6%) | 0.6171 |
| Posaconazole/itraconazole | ---- | 26 (13.9%) | 1 (0.5%) | <0.0001 |
| RRT of any kind | ---- | 1 (0.5%) | 0 (0%) | ---- |
| ACE – angiotensin-converting enzyme inhibitors; ARB – angiotensin II receptor blockers; eGFR – estimated glomerular filtration rate. ‘----’ – no statistical analysis available. All categorical values are represented by a number followed by the percentage in parentheses. All continuous values are represented by a median followed by the interquartile range in parentheses. | ||||