17 May 2022 : Original article
Tacrolimus-Induced Neurotoxicity in Early Post-Liver Transplant Saudi Patients: Incidence and Risk Factors
Dema A. Alissa1ABCDEF*, Delal Alkortas1AE, Mohammed Alsebayel2AE, Rawan Abdullah Almasuood3EF, Wejdan Aburas
3EF, Tahani Altamimi4F, Edward Bentz Devol 5CD, Ahmed H. Al-jedai 16ADE
DOI: 10.12659/AOT.935938
Ann Transplant 2022; 27:e935938
Table 3 Management for liver transplant recipients who developed ECIIN.
| Switching tacrolimus to cyclosporine* | Reduction in tacrolimus dose** | Temporarily dose hold# | No tacrolimus changes## | |
|---|---|---|---|---|
| Seizures | 23 | 3 | 2 | 1 |
| Coma | 1 | 2 | 0 | 1 |
| Psychosis | 6 | 3 | 1 | 3 |
| Agitation | 7 | 3 | 0 | 5 |
| Tremors | 4 | 2 | 0 | 0 |
| Confusion | 3 | 4 | 0 | 1 |
| Twitching | 0 | 1 | 0 | 0 |
| Behavioral changes | 1 | 0 | 0 | 0 |
| Low Level of consciousness | 0 | 0 | 0 | 1 |
| * A total of 5 patients had psychosis (2 with confusion, 2 with agitation, and 1 with tremors); ** a total of 3 patients with psychosis (2 with confusion and 1 with agitation), 1 had agitation and confusion, 1 had twitching and tremors, and 1 had seizures then coma; # One patient developed psychosis with agitation; ## a total of 2 patients had agitation (1 with seizures and 1 with low level of consciousness. | ||||