Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

17 May 2022: Original Paper

Tacrolimus-Induced Neurotoxicity in Early Post-Liver Transplant Saudi Patients: Incidence and Risk Factors

Dema A. Alissa 1ABCDEF* , Delal Alkortas 1AE , Mohammed Alsebayel 2AE , Rawan Abdullah Almasuood 3EF , Wejdan Aburas 3EF , Tahani Altamimi 4F , Edward Bentz Devol 5CD , Ahmed H. Al-jedai 16ADE

DOI: 10.12659/AOT.935938

Ann Transplant 2022; 27:e935938

Table 5 Neurotoxic agents used for liver transplant recipients who developed ECIIN.

All patients (n=338)Patients that developed ECIIN (n=63)P-value
Acyclovir14 (4%)4 (29%; 8.39–58.10)0.3053
Carbapenems109 (32%)35 (32%; 23.49–41.73)
Cephalosporins91 (27%)16 (18%; 10.40–26.98)0.8752
Diphenhydramine168 (50%)35 (21%; 14.96–27.76)0.3301
Fentanyl316 (93%)62 (20%; 15.39–24.43)0.0923
Ketamine4 (1%)2 (50%; 6.76–93.24)0.1593
Linezolid17 (5%)8 (47%; 22.98–72.19)
Macrolides6 (2%)1 (17%; 0.42–64.12)1.0000
Metoclopramide268 (79%)54 (20%; 15.51–25.46)0.2267
Midazolam235 (70%)52 (22%; 16.99–27.98)
Morphine8 (2%)2 (25%; 3.19–65.09)0.6458
Propofol97 (29%)27 (28%; 19.21–37.86)
Serotonin release inhibitors30 (9%)8 (27%; 12.28–45.89)0.2274
Tramadol203 (60%)42 (21%; 15.34–26.92)0.2565
Tricyclic antidepressants1 (0%)1 (100%; 2.50–100)0.1864
Carbamazepine2 (1%)1 (50%; 1.26–98.74)0.3385
Haloperidol57 (17%)23 (40%; 27.56–54.18)
Lorazepam93 (28%)30 (32%; 22.93–42.75)
Pregabalin2 (1%)1 (50%; 1.26–98.74)0.3385
Risperidone9 (3%)5 (56%; 2.12–86.30)
Olanzapine3 (1%)3 (100%; 29.24–100)

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358