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26 July 2022: Original Paper

Donor CYP3A5 Expression Decreases Renal Transplantation Outcomes in White Renal Transplant Recipients

Karola Warzyszyńska 1ABCDEFG* , Michał Zawistowski 12BCDE , Edyta Karpeta 3B , Agnieszka Jałbrzykowska 4B , Maciej Kosieradzki 1DE

DOI: 10.12659/AOT.936276

Ann Transplant 2022; 27:e936276

Table 1 Baseline demographics and clinicopathological characteristics of patients and brain-dead kidney donors.

VariableAll patientsN=95Subgroup (by donor CYP3A5 expression status)Subgroup (by recipient CYP3A5 expression status)
D+ (n=16)D− (n=79)R+ (n=14)R− (n=81)
Donor gender: male66 (69.5)12 (75.0)54 (68.4)10 (10.0)56 (69.1)
Donor age (years)45 [38–52]37.5 [35–46.75]47 [40–52]45 [42.25–51]45 [38–52]
Donor BMI (kg/m)25.5 [23.1–28.4]23.1 [21.4–24.9]25.7 [23.7–28.7]25.0 [21.7–26.1]25.5 [23.6–28.4]
Cause of death
Brain injury31 (32.6)4 (25.0)27 (34.2)6 (42.9)25 (30.9)
Cardiovascular event54 (56.8)8 (50.0)46 (58.2)5 (35.7)49 (60.5)
Other10 (10.5)4 (25.0)6 (7.6)3 (28.6)7 (8.6)
Extended criteria donor6 (6.3)0 (0.0)6 (7.6)1 (7.1)5 (6.2)
Non-scaled US KDRI2.58±0.482.51±0.452.59±0.492.60±0.462.57±0.49
Serum creatinine (mg/dL)1.04 [0.80–1.53]0.98 [0.81–1.31]1.08 [0.80–1.71]1.04 [0.84–1.34]1.04 [0.80–1.65]
Patient gender: male66 (69.5)9 (56.3)57 (72.2)8 (57.1)58 (71.6)
Patient age (years)43.8±11.146.7±10.943.3±11.239.6±10.944.6±11.1
Patient BMI (kg/m)24.3±3.826.2±3.923.9±3.723.9±3.324.4±3.9
Cause of CKD
Glomerulonephritis49 (51.6)7 (43.8)42 (53.2)9 (64.3)40 (49.4)
ADPKD14 (14.7)1 (6.3)13 (16.5)1 (7.1)13 (16.1)
Hypertensive nephropathy9 (9.5)1 (6.3)8 (10.1)0 (0.0)9 (11.1)
Diabetic nephropathy5 (5.3)2 (12.5)3 (3.8)1 (7.1)4 (4.9)
Other10 (10.5)3 (18.3)7 (8.9)2 (14.3)8 (9.9)
Unknown8 (8.4)2 (12.5)6 (7.6)1 (7.1)7 (8.6)
Retransplantation16 (16.8)5 (31.3)11 (13.9)1 (7.1)15 (18.5)
Maximal PRA >0%25 (26.3)5 (33.3)20 (25.6)5 (35.7)20 (25.3)
Pre-transplant PRA >0%14 (14.7)3 (20.0)11 (14.1)2 (14.3)12 (15.2)
HLA mismatches
0–244 (46.3)8 (50.0)36 (45.6)5 (35.7)39 (48.2)
3–445 (47.4)8 (50.0)37 (46.8)7 (50.0)38 (46.9)
5–66 (6.3)0 (0.0)6 (7.6)2 (14.3)4 (4.9)
Induction immunosuppression43 (45.3)11 (68.8)31 (39.7)7 (50.0)35 (43.8)
Categorical variables reported as number (%) and assessed using the chi-squared or Fisher’s exact test (expected n < 5). Continuous data reported as median [Q1–Q3] or mean±SD based on the normality of data, and evaluated using Mann-Whitney U or test, as appropriate. D+ – donor CYP3A5 expressor; D− – donor CYP3A5 non-expressor; R+ – recipient CYP3A5 expressor; R− – recipient CYP3A5 non-expressor; KDRI – unscaled US Kidney Donor Risk Index; ADPKD – autosomal dominant polycystic kidney disease; PRA – panel reactive antibody; SD – standard deviation.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358