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26 July 2022: Original Paper

Donor CYP3A5 Expression Decreases Renal Transplantation Outcomes in White Renal Transplant Recipients

Karola Warzyszyńska 1ABCDEFG* , Michał Zawistowski 12BCDE , Edyta Karpeta 3B , Agnieszka Jałbrzykowska 4B , Maciej Kosieradzki 1DE

DOI: 10.12659/AOT.936276

Ann Transplant 2022; 27:e936276

Table 3 Cox proportional hazards regression analysis for graft loss.

CovariatesUnivariableMultivariable*
HR (95% CI)P valueHR (95% CI)P value
Donor CYP3A5 expressor8.168 (1.898–35.140)10.610 (2.278–49.420)
Donor’s sex (male)0.476 (0.116–1.957).303
Donor’s age1.048 (0.959–1.145).304
Donor’s BMI0.920 (0.770–1.101).364
Donor’s serum creatinine, mg/dL0.702 (0.232–2.128).532
Machine perfusion0.186 (0.037–0.920)
KDRI3.128 (0.854–11.451).0854.950 (1.065–23.020)
PRA max >00.702 (0.116–4.233).699
Recipient CYP3A5 expressor0.725 (0.089–5.913).764
Recipient’s sex (male)0.996 (0.218–4.546).996
Recipient’s age0.953 (0.889–1.020).165
Recipient’s BMI1.050 (0.868–1.269).615
Retransplantation5.634 (1.398–22.699)
Induction immunosuppression3.155 (0.622–15.991).165
Delayed graft function1.562 (0.368–6.623).545
Biopsy-proven acute rejection within the first post-transplant month10.431 (2.012–54.079)
Biopsy-proven acute rejection within the first post-transplant year11.757 (2.775–49.811)
HR – hazard ratio; CI – confidence interval; BMI – body mass index; KDRI – unscaled US Kidney Donor Risk Index; PRA – Panel Reactive Antibody; HLA – human leukocyte antigen.
* Concordance (standard error), 0.866 (0.055); R2, 0.776; N, 95; number of events, 8.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358