26 July 2022>: Original Paper
Donor CYP3A5 Expression Decreases Renal Transplantation Outcomes in White Renal Transplant Recipients
Karola Warzyszyńska 1ABCDEFG* , Michał Zawistowski 12BCDE , Edyta Karpeta 3B , Agnieszka Jałbrzykowska 4B , Maciej Kosieradzki 1DEDOI: 10.12659/AOT.936276
Ann Transplant 2022; 27:e936276
Table 3 Cox proportional hazards regression analysis for graft loss.
Covariates | Univariable | Multivariable* | ||
---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Donor CYP3A5 expressor | 8.168 (1.898–35.140) | 10.610 (2.278–49.420) | ||
Donor’s sex (male) | 0.476 (0.116–1.957) | .303 | ||
Donor’s age | 1.048 (0.959–1.145) | .304 | ||
Donor’s BMI | 0.920 (0.770–1.101) | .364 | ||
Donor’s serum creatinine, mg/dL | 0.702 (0.232–2.128) | .532 | ||
Machine perfusion | 0.186 (0.037–0.920) | |||
KDRI | 3.128 (0.854–11.451) | .085 | 4.950 (1.065–23.020) | |
PRA max >0 | 0.702 (0.116–4.233) | .699 | ||
Recipient CYP3A5 expressor | 0.725 (0.089–5.913) | .764 | ||
Recipient’s sex (male) | 0.996 (0.218–4.546) | .996 | ||
Recipient’s age | 0.953 (0.889–1.020) | .165 | ||
Recipient’s BMI | 1.050 (0.868–1.269) | .615 | ||
Retransplantation | 5.634 (1.398–22.699) | |||
Induction immunosuppression | 3.155 (0.622–15.991) | .165 | ||
Delayed graft function | 1.562 (0.368–6.623) | .545 | ||
Biopsy-proven acute rejection within the first post-transplant month | 10.431 (2.012–54.079) | |||
Biopsy-proven acute rejection within the first post-transplant year | 11.757 (2.775–49.811) | |||
HR – hazard ratio; CI – confidence interval; BMI – body mass index; KDRI – unscaled US Kidney Donor Risk Index; PRA – Panel Reactive Antibody; HLA – human leukocyte antigen. * Concordance (standard error), 0.866 (0.055); R2, 0.776; N, 95; number of events, 8. |