26 July 2022: Original Paper
Donor CYP3A5 Expression Decreases Renal Transplantation Outcomes in White Renal Transplant Recipients
Karola Warzyszyńska 1ABCDEFG* , Michał Zawistowski 12BCDE , Edyta Karpeta 3B , Agnieszka Jałbrzykowska 4B , Maciej Kosieradzki 1DEDOI: 10.12659/AOT.936276
Ann Transplant 2022; 27:e936276
Table 4 Logistic regression models to estimate secondary endpoints (biopsy-proven acute rejection, proteinuria, and delayed graft function) using donor CYP3A5 expressor status as a predictive factor.
| OR | 95% CI | P value | AUC | R2N | Accuracy | Overall model test | |
|---|---|---|---|---|---|---|---|
| BPAR within the 1 post-transplant year as a dependent variable | |||||||
| Crude | 2.96 | 0.77–11.38 | .115 | 0.59 | 0.04 | 87% | χ: 2.28, df: 1, P=.131 |
| BPAR between the 2 and the 12 post-transplant month as a dependent variable | |||||||
| Crude | 5.53 | 1.44–21.24 | .013 | 0.66 | 0.12 | 88% | χ: 5.77, df: 1, P=.016 |
| Model 1 | 4.36 | 1.08–17.6 | .038 | 0.70 | 0.16 | 89% | χ: 7.85, df: 2, P=.020 |
| Proteinuria within the 1 post-transplant month as a dependent variable | |||||||
| Crude | 1.69 | 0.47–6.08 | .420 | 0.54 | 0.01 | 82% | χ: 0.62, df: 1, P=.432 |
| Proteinuria within the 1 post-transplant year as a dependent variable | |||||||
| Crude | 4.03 | 1.12–14.58 | .033 | 0.63 | 0.08 | 86% | χ: 4.17, df: 1, P=.0.41 |
| Model 2 | 5.90 | 1.40–24.82 | .015 | 0.73 | 0.20 | 88% | χ: 10.94, df: 3, P=.012 |
| Proteinuria between the 2 and 3 post-transplant year as a dependent variable | |||||||
| Crude | 4.19 | 1.23–14.24 | .022 | 0.61 | 0.08 | 81% | χ: 4.96, df: 1, P=.026 |
| Model 3 | 4.49 | 1.28–15.72 | .019 | 0.65 | 0.12 | 83% | χ: 7.01, df: 2, P=.030 |
| Delayed graft function | |||||||
| Crude | 0.44 | 0.12–1.70 | .235 | 0.55 | 0.02 | 68% | χ: 1.58, df: 1, P=.208 |
| OR – odds ratio; CI – confidence interval; R – Nagelkerke’s R; AUC – area under the curve. adjusted for patient’s body mass index. adjusted for patient’s age and donor’s sex. adjusted for donor’s sex. No statistically significant associations were observed for BPAR within the first post-transplant month. | |||||||