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26 July 2022: Original Paper

Donor CYP3A5 Expression Decreases Renal Transplantation Outcomes in White Renal Transplant Recipients

Karola Warzyszyńska 1ABCDEFG* , Michał Zawistowski 12BCDE , Edyta Karpeta 3B , Agnieszka Jałbrzykowska 4B , Maciej Kosieradzki 1DE

DOI: 10.12659/AOT.936276

Ann Transplant 2022; 27:e936276

Supplementary Table 2 Estimated glomerular filtration rate (eGFR) within three-year follow-up depending on the presence of the renal or recipient CYP3A5*1 allele variant.

OutcomeAll patients (N=95)Subgroup (by donor CYP3A5 expression status)P valueSubgroup (by recipient CYP3A5 expression status)P value
D+ (n=16)D− (n=79)R+ (n=14)R− (n=81)
eGFR [ml/min/1.73 m]
 7 day26.59 [13.65–41.83]23.86 [12.65–35.35]27.79 [13.71–43.25].92027.90 [20.01–38.49]24.67 [13.31–42.39].791
 14 day43.44 (19.23)44.92 (20.75)43.14 (19.03).73743.98 (13.42)43.34 (20.13).910
 1 month51.03 (17.72)47.50 (19.46)51.74 (17.39).38646.47 (14.48)51.81 (18.18).300
 6 month56.00 [43.27–69.70]50.27 [43.25–65.33]56.43 [44.08–70.19].85954.53 [47.85–62.21]56.00 [42.35–74.01].981
 1 year56.41 [47.32–68.17]57.88 [46.18–70.89]55.92 [47.34–68.17].92149.70 [46.37–63.48]58.61 [47.47–69.70].314
 2 year57.29 (21.23)64.27 (29.51)56.02 (19.35).20048.08 (15.36)58.83 (21.76).105
 3 year57.33 (20.96)59.27 (32.44)57.03 (18.86).820* 45.46 (16.73)59.55 (21.01).020
Continuous data reported as median [Q1–Q3] or mean±SD, as appropriate. D+ – donor CYP3A5 expressor; D− – donor CYP3A5 non-expressor; R+ – recipient CYP3A5 expressor; R− – recipient CYP3A5 non-expressor; eGFR – estimated glomerular filtration rate calculated from the MDRD formula; SD – standard deviation.
* Welch’s t-test was used due to violation of the assumption of equal variances (Levene’s test, =.021).

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358