07 June 2022 : Original article
Phosphatidylethanol (PEth) for Monitoring Sobriety in Liver Transplant Candidates: Preliminary Results of Differences Between Alcohol-Related and Non-Alcohol-Related Cirrhosis Candidates
Jan-Paul Gundlach1EF*, Felix Braun1AD, Finn Mötter1B, Alexander Bernsmeier1CDE, Pablo Barrio2E, Nicola Ehmke1B, Rainer Günther3B, Holger Hinrichsen4A, Thomas Becker1AD, Wolfgang Weinmann
5B, Alexandra Schröck6C, Michel Yegles7C, Friedrich Martin Wurst8ACDE
DOI: 10.12659/AOT.936293
Ann Transplant 2022; 27:e936293
Table 2 Results of positive biomarkers uEtG, hEtG, and PEth and patient self-assessment with the AUDIT and TLFB questionnaires.
| Group (number of patients) | uEtG (mg/L)n=65 | hEtG (pg/mg)n=65 | PEth 16: 0/18: 1 (ng/mL)n=66 | AUDIT (points) | TLFB (weeks pos.) | |||
|---|---|---|---|---|---|---|---|---|
| 0 | ≥1 | <2 | >2 | |||||
| Alcoholic cirrhosis | Waiting list active (11) | 0 | 1 | 4 | 2 | 9 | 0 | 1 |
| Median value (range) | 78.0 | 59.0 (24.1–80.7) | 2 (2–8) | |||||
| Waiting list inactive (6) | 0 | 3 | 5 | 0 | 6 | 2 | 5 | |
| Median value (range) | 20.0 (19.6–53.8) | 49.8 (32.5–606.0) | 4 (3–9) | |||||
| Not listed (8) | 1 | 1 | 4 | 1 | 7 | 0 | 6 | |
| Median value (range) | 0.4 | 67.2 | 40.1 (20.6–94.0) | 8 (2–16) | ||||
| Other liver disease | Waiting list active (34) | 3 | 1 | 18 | 0 | 10 | 3 | 7 |
| Median value (range) | 3.0 (0.2–3.6) | 41.8 | 62.0 (25.3–251.0) | 3 (1–4) | ||||
| Waiting list inactive (2) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Median value (range) | ||||||||
| Not listed (5) | 1 | 3 | 3 | 4 | 1 | 0 | 2 | |
| Median value (range) | 0.4 | 13.7 (7.3–61.8) | 61.5 (33.6–74.1) | 2 | ||||