16 August 2022>: Original Paper
Evaluation of Deceased Donor Kidney Transplantation in the Eurotransplant Senior Program in Comparison to Standard Allocation
Nelly Delaly Eklou 1BCDE , Bernd M. Jänigen 2E , Przemylsaw Pisarski 2E , Gerd Walz 1E , Johanna Schneider 1ABCDEF*DOI: 10.12659/AOT.936514
Ann Transplant 2022; 27:e936514
Table 2 Immunosuppressive therapy, acute rejections, and graft function.
Parameter | ESPn=116 | ETKASn=111 | p-value |
---|---|---|---|
Induction therapy | |||
Antithymocyte globulin, n (%) | 11 (9.5) | 22 (19.8) | * |
Basiliximab, n (%) | 94 (81.0) | 72 (64.9) | * |
Unknown, n (%) | 11 (9.5) | 17 (15.3) | 0.227 |
Maintenance therapy | |||
Tacrolimus, n (%) | 114 (98.3) | 107 (96.4) | 0.438 |
Everolimus, n (%) | 0 (0.0) | 5 (4.5) | * |
Ciclosporine, n (%) | 2 (1.7) | 4 (3.6) | 0.438 |
Prednisone, n (%) | 106 (93.0) | 103 (92.8) | 1.000 |
Mycophenolate, n (%) | 108 (93.1) | 101 (91.0) | 0.628 |
Mycophenolate, full dose, n (%) | 97 (83.6) | 93 (83.8) | 1.000 |
Mycophenolate, reduced dose, n (%) | 11 (9.5) | 8 (7.2) | 0.635 |
Triple immunosuppressive therapy as maintenance therapy | 105 (96.3) | 102 (96.2) | 1.000 |
Rejections, n (%) | 28 (24.1) | 26 (23.4) | 1.000 |
Time of rejection (months) | 16.2±5.7 | 5.4±1.6 | 0.084 |
DGF, n (%) | 18 (15.5) | 17 (15.3) | 1.000 |
Graft loss, n (%) | 21 (18.1) | 9 (8.1) | * |
Duration between transplantation and graft loss (months) | 29.3±7.1 | 5.4±4.0 | * |
Graft loss within the first year, n (%) | 11 (9.5) | 8 (7.2) | 0.635 |
Cause of graft loss | |||
Primary nonfunction, n (%) | 5 (4.3) | 4 (3.6) | 1.000 |
Rejection, n (%) | 3 (2.6) | 1 (0.9) | 0.622 |
Infection, n (%) | 5 (4.3) | 2 (1.8) | 0.447 |
Thromboembolic events, n (%) | 4 (3.4) | 1 (0.9) | 0.370 |
Unknown, n (%) | 4 (3.4) | 1 (0.9) | 0.370 |
Data are presented as mean±standard error of the mean (SEM) unless otherwise indicated. Note that the percentage of different rejections refers to the total number of rejections. ABMR – antibody-mediated rejection; DGF – delayed graft function; ESP – Eurotransplant Senior Program; ETKAS – Eurotransplant Kidney Allocation System. * |