Evaluation of Deceased Donor Kidney Transplantation in the Eurotransplant Senior Program in Comparison to Standard Allocation

16 August 2022 : Original article

Nelly Delali Eklou^1BCDE, Bernd M. Jänigen^2E, Przemyslaw Pisarski^2E, Gerd Walz^1E, Johanna Schneider^1ABCDEF*

DOI: 10.12659/AOT.936514

Ann Transplant 2022; 27:e936514

Background Material and Methods Results Discussion Conclusions References

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Table 5 Risk factors for mortality.

	Univariate			Multivariate
	Odds ratio	95% CI	p-value	Odds ratio	95% CI	p-value
Age	1.11	1.06–1.16	^*	1.08	1.02–1.14	0.008^*
Male sex	1.82	0.94–3.52	0.077
Body mass index	0.99	0.93–1.06	0.758
ESKD due to diabetic nephropathy	2.51	1.11–5.68	^*	1.50	0.54–4.18	0.432
ESKD due to hypertensive disorder	1.07	0.32–3.59	0.919
Diabetes	1.78	0.95–3.32	0.071
Cardiac disease	3.43	1.76–6.67	^*	2.37	0.91–6.17	0.078
Immunosuppressive therapy before transplantation	0.58	0.26–1.28	0.174
Chemotherapy before transplantation	0.39	0.05–3.29	0.386
Time on dialysis	0.99	0.98–1.00	^*	1.00	0.99–1.00	0.424
Cold ischemia time	1.00	1.00–1.00	0.545
Warm ischemia time	1.00	0.99–1.01	0.713
Number of HLA mismatches	1.44	1.18–1.75	^*	1.32	1.05–1.67	^*
Number of previous diseases	1.41	1.13–1.76	^*	0.97	0.69–1.35	0.836
Antithymocyte globulin	1.06	0.49–2.30	0.881
CMV serostatus
D−/R−	0.63	0.28–1.41	0.264
D−/R+	0.73	0.37–1.46	0.378
D+/R−	3.27	1.68–6.36	^*	3.55	1.64–7.68	^*
D+/R+	0.55	0.29–1.05	0.070
DGF	1.30	0.60–2.79	0.502
Number of leucocytes before transplantation	1.00	1.00–1.00	0.116
Serum protein level before transplantation	1.11	0.74–1.66	0.615
C-reactive protein at time of transplantation	1.02	0.99–1.04	0.219
CI – confidence interval; CMV – cytomegalovirus; D – donor; DGF – delayed graft function; ESKD – end-stage kidney disease; HLA – human leucocyte antigen; R – recipient. ^*

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