19 July 2022>: Original Paper
Graft Inflow Modulation in Living-Donor Liver Transplantation: Hepatic Hemodynamic Changes in Splenic Artery Ligation and Splenectomy
Che-Min Su ABCDEF , Tsung-Ching Chou ABD , Tsung-Han Yang ABD , Yih-Jyh Lin ABDEF*DOI: 10.12659/AOT.936609
Ann Transplant 2022; 27:e936609
Table 1 Clinical characteristics of all recipients and donors.
VariablesModulation | Group No. | GIM group (SAL+splenectomy) | P-value |
---|---|---|---|
N | 63 | 36 (17+19) | |
Recipient | |||
Age, years | 58 (51–62) | 56 (49–63) | 0.613 |
Sex (M), n (%) | 42 (66.7) | 23 (63.9) | 0.779 |
BMI, kg/m | 25.1 (23.2–29.6) | 25.2 (23.5–26.5) | 0.741 |
Hepatitis profile | 0.840 | ||
HBV+/HCV+ | 3 (4.8) | 2 (6.7) | |
HBV+ | 31 (49.2) | 15 (41.7) | |
HCV+ | 13 (20.6) | 8 (22.2) | |
Negative | 16 (25.4) | 11 (30.6) | |
Disease indication, n (%) | 0.152 | ||
Acute/acute on chronic liver failure | 16 (25.4) | 4 (16.7) | |
Decompensated cirrhosis | 23 (36.5) | 19 (52.8) | |
Hepatocellular carcinoma | 24 (38.1) | 13 (36.1) | |
MELD | 13 (9–30) | 15 (11–23) | 0.633 |
MELD ≥25, n (%) | 18 (28.6) | 8 (22.2) | 0.490 |
ABO incompatible, n (%) | 11 (17.5) | 7 (19.4) | 0.806 |
Donor | |||
Donor age, y | 31 (25–38) | 31 (23–36) | 0.267 |
Donor age ≥40, n (%) | 11 (17.5) | 5 (13.9) | 0.642 |
Sex (M), n (%) | 40 (63.5) | 16 (44.4) | 0.066 |
BMI, kg/m | 23.5 (20.7–25.3) | 22.3 (19.6–23.6) | 0.046 |
Liver graft | |||
Actual GRWR (%) | 1.04 (0.90–1.19) | 0.91 (0.77–1.11) | 0.022 |
GRWR | 9 (14.3) | 11 (30.6) | 0.027 |
Graft weight, g | 680 (571–812) | 612 (541–703) | 0.017 |
Graft type, n (%) | 0.80 | ||
Right lobe | 56 (88.9) | 31 (86.1) | |
Left lobe | 5 (7.9) | 4 (11.1) | |
Right lobe with MHV | 1 (1.6) | 0 | |
Right posterior section | 1 (1.6) | 1 (2.8) | |
SAL – splenic artery ligation; BMI – body mass index; HBV – hepatitis B virus; HCV – hepatitis C virus; MELD – model of end-stage liver disease; GRWR – graft-to-recipient weight ratio. Continuous variables are expressed as the median (IQR). Categorical variables are expressed as number of patients (percentage). |