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19 July 2022: Original Paper

Graft Inflow Modulation in Living-Donor Liver Transplantation: Hepatic Hemodynamic Changes in Splenic Artery Ligation and Splenectomy

Che-Min Su ABCDEF , Tsung-Ching Chou ABD , Tsung-Han Yang ABD , Yih-Jyh Lin ABDEF*

DOI: 10.12659/AOT.936609

Ann Transplant 2022; 27:e936609

Table 1 Clinical characteristics of all recipients and donors.

VariablesModulationGroup No.GIM group (SAL+splenectomy)P-value
N6336 (17+19)
Recipient
 Age, years58 (51–62)56 (49–63)0.613
 Sex (M), n (%)42 (66.7)23 (63.9)0.779
 BMI, kg/m25.1 (23.2–29.6)25.2 (23.5–26.5)0.741
 Hepatitis profile0.840
  HBV+/HCV+3 (4.8)2 (6.7)
  HBV+31 (49.2)15 (41.7)
  HCV+13 (20.6)8 (22.2)
  Negative16 (25.4)11 (30.6)
 Disease indication, n (%)0.152
  Acute/acute on chronic liver failure16 (25.4)4 (16.7)
  Decompensated cirrhosis23 (36.5)19 (52.8)
  Hepatocellular carcinoma24 (38.1)13 (36.1)
 MELD13 (9–30)15 (11–23)0.633
 MELD ≥25, n (%)18 (28.6)8 (22.2)0.490
 ABO incompatible, n (%)11 (17.5)7 (19.4)0.806
Donor
 Donor age, y31 (25–38)31 (23–36)0.267
 Donor age ≥40, n (%)11 (17.5)5 (13.9)0.642
 Sex (M), n (%)40 (63.5)16 (44.4)0.066
 BMI, kg/m23.5 (20.7–25.3)22.3 (19.6–23.6)0.046
Liver graft
 Actual GRWR (%)1.04 (0.90–1.19)0.91 (0.77–1.11)0.022
 GRWR9 (14.3)11 (30.6)0.027
 Graft weight, g680 (571–812)612 (541–703)0.017
 Graft type, n (%)0.80
  Right lobe56 (88.9)31 (86.1)
  Left lobe5 (7.9)4 (11.1)
  Right lobe with MHV1 (1.6)0
  Right posterior section1 (1.6)1 (2.8)
SAL – splenic artery ligation; BMI – body mass index; HBV – hepatitis B virus; HCV – hepatitis C virus; MELD – model of end-stage liver disease; GRWR – graft-to-recipient weight ratio. Continuous variables are expressed as the median (IQR). Categorical variables are expressed as number of patients (percentage).

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358