Graft Inflow Modulation in Living-Donor Liver Transplantation: Hepatic Hemodynamic Changes in Splenic Artery Ligation and Splenectomy

19 July 2022 : Original article

Che-Min Su^1ABCDEF, Tsung-Ching Chou^1ABD, Tsung-Han Yang^1ABD, Yih-Jyh Lin^1ABDEF*

DOI: 10.12659/AOT.936609

Ann Transplant 2022; 27:e936609

Background Material and Methods Results Discussion Conclusions References

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Table 3 Clinical characteristics of all recipients and donors in the modulation group.

VariablesModulation	Subgroup 1SAL	Subgroup 2Slenectomy	P
N	17	19	P
Recipient
Age, years	58 (52–64)	54 (49–63)	0.253
Sex (M), n (%)	14 (82.4)	9 (47.4)	0.029
BMI, kg/m	24.9 (23.4–26.1)	25.4 (22.9–31.2)	0.428
Hepatitis profile			0.180
HBV+/HCV+	0	2 (10.5)
HBV+	10 (58.8)	5 (26.3)
HCV+	3 (17.6)	5 (26.3)
Negative	4 (23.5)	7 (36.8)
Disease indication, n (%)			0.124
Acute/acute on chronic liver failure	3 (17.6)	1 (5.3)
Decompensated cirrhosis	6 (35.3)	13 (68.4)
Hepatocellular carcinoma	8 (47.1)	5 (26.3)
MELD	15 (10–24)	14 (12–19)	0.799
MELD ≥25, n (%)	4 (23.5)	3 (17.6)	0.858
ABO incompatible, n (%)	4 (21.1)	4 (21.1)	0.797
Donor
Donor age, y	26 (23–33)	33 (23–37)	0.136
Donor age ≥40, n (%)	0	5 (26.3)	0.023
Sex (M), n (%)	11 (64.7)	5 (26.3)	0.021
BMI, kg/m	20.4 (18.4–23.7)	23.2 (21.2–23.6)	0.090
Liver graft
Actual GRWR (%)	0.99 (0.84–1.12)	0.83 (0.71–0.99)	0.038
GRWR <0.8%, n (%)	2 (11.8)	9 (47.4)	0.021
Graft weight, g	658 (575–782)	577 (452–682)	0.022
Graft type, n (%)			0.74
Right lobe	17 (100)	14 (73.7)
Left lobe	0	4 (21.1)
Right lobe with MHV	0	0
Right posterior section	0	1 (5.3)
SAL – splenic artery ligation; BMI – body mass index; HBV – hepatitis B virus; HCV – hepatitis C virus; MELD – model of end-stage liver disease; GRWR – graft-to-recipient weight ratio. Continuous variables are expressed as median (IQR). Categorical variables are expressed as number of patients (percentage).

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