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19 July 2022: Original Paper

Graft Inflow Modulation in Living-Donor Liver Transplantation: Hepatic Hemodynamic Changes in Splenic Artery Ligation and Splenectomy

Che-Min Su ABCDEF , Tsung-Ching Chou ABD , Tsung-Han Yang ABD , Yih-Jyh Lin ABDEF*

DOI: 10.12659/AOT.936609

Ann Transplant 2022; 27:e936609

Table 4 Operative characteristics of all recipients and donors in the modulation group.

VariablesModulationSubgroup 1SALSubgroup 2SlenectomyP
 Cold ischaemic time, min185 (154–234)164 (137–196)0.149
 Anhepatic phase, min79 (66–107)78 (59–94)0.366
 Operation time, min695 (594–838)657 (552–745)0.199
 Blood loss3100 (1225–4150)2800 (1900–6500)0.334
 SFSS3 (17.6)1 (5.3)0.238
 EAD02 (10.5)0.169
 Hospital stay21 (19–28)26 (21–35)0.172
 ICU stay11 (10–13)13 (11–18)0.009
Severe postoperative complications* 0.391
 3a6 (35.3)7 (36.8)
 3b02 (10.5)
 4a1 (5.9)0
 4c01 (5.3)
Hospital mortality01 (5.3)
Specific postoperative complications
 Hepatic artery thrombosis/pseudoaneurysm +1 (5.9)00.284
 Portal vein thrombosis02 (10.5)0.169
 Hepatic vein thrombosis01 (5.3)0.337
 Bile leakage/stricture4 (23.5)2 (10.5)0.296
Liver hemodynamics
 Initial portal flow, ml/min/100 g292 (238–357)319 (250–430)0.274
 Initial HA flow, ml/min70 (43–85)40 (27–56)0.013
 Final portal flow, ml/min/100 g233 (211–273)203 (150–270)0.188
 Final HA flow, ml/min83 (52–137)73 (49–110)0.362
Decreased PVF (%)14.3 (11.0–23.8)41.8 (23.6–50.3)0.002
Increased HAF (%)22.5 (5.3–74.7)83.4 (3.8–195.2)0.129
SAL – splenic artery ligation; SFSS – small-for-size syndrome; EAD – early allograft dysfunction; ICU – Intensive Care Unit; PVF – portal vein flow; HAF – hepatic artery flow.
* Clavien-Dindo classification. Continuous variables are expressed as the median (IQR).
Categorical variables are expressed as number of patients (percentage).

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358