12 August 2022: Original Paper
Retrospective Study from a Single Center in Romania of 347 Renal Transplant Patients Treated with Tacrolimus, Mycophenolate, and Steroids to Evaluate the Association Between Anti-HLA Antibodies and 5-Year Graft Survival
Ion Mărunţelu 12ABCDEF , Claudiu Eduard Nistor 2CEF* , Bogdan Mihai Cristea 2CE , Corina Andreea Rotarescu 12BCD , Andreea Mirela Caragea 2B , Maria Tizu 2B , Ileana Constantinescu 12ADDOI: 10.12659/AOT.937267
Ann Transplant 2022; 27:e937267
Table 1 Characteristics of patients with a kidney transplant.
| Patients with pre-existing HLA antibodies | Patients without pre-existing HLA antibodies | P value | |
|---|---|---|---|
| n (%) | n=27 (7.78%) | n=320 (92.22%) | |
| Age (mean±SD) | 40.96±11.65 | 46.72±11.61 | 0.0247* |
| Sex | 0.002** | ||
| Male n (%) | 10 (37.03%) | 219 (68.44%) | |
| Female n (%) | 17 (62.97%) | 101 (31.56%) | |
| Donor type | 0.311 | ||
| Cadaveric donor n (%) | 15 (55.55%) | 139 (43.44%) | |
| Living related donor n (%) | 12 (44.45%) | 181 (56.56%) | |
| Tacrolimus (mean±SD) | 5.9±1.55 | 6.22±1.68 | 0.0174*** |
| * , a significant association, between ages and presensitization; ** , a significant association, between sex and presensitization; *** , a significant association, between tacrolimus and presensitization. HLA – human leukocyte antigen. | |||