Retrospective Study from a Single Center in Romania of 347 Renal Transplant Patients Treated with Tacrolimus, Mycophenolate, and Steroids to Evaluate the Association Between Anti-HLA Antibodies and 5-Year Graft Survival

12 August 2022 : Original article

Ion Mărunţelu^12ABCDEF, Claudiu Eduard Nistor

^2CEF*, Bogdan Mihai Cristea^2CE, Corina Andreea Rotarescu^12BCD, Andreea Mirela Caragea^2B, Maria Tizu^2B, Ileana Constantinescu^12AD

DOI: 10.12659/AOT.937267

Ann Transplant 2022; 27:e937267

Background Material and Methods Results Discussion Conclusions References

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Table 1 Characteristics of patients with a kidney transplant.

	Patients with pre-existing HLA antibodies	Patients without pre-existing HLA antibodies	P value
n (%)	n=27 (7.78%)	n=320 (92.22%)
Age (mean±SD)	40.96±11.65	46.72±11.61	0.0247^*
Sex			0.002^**
Male n (%)	10 (37.03%)	219 (68.44%)
Female n (%)	17 (62.97%)	101 (31.56%)
Donor type			0.311
Cadaveric donor n (%)	15 (55.55%)	139 (43.44%)
Living related donor n (%)	12 (44.45%)	181 (56.56%)
Tacrolimus (mean±SD)	5.9±1.55	6.22±1.68	0.0174^***
^* , a significant association, between ages and presensitization; ^ , a significant association, between sex and presensitization; ^* , a significant association, between tacrolimus and presensitization. HLA – human leukocyte antigen.

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