Retrospective Study from a Single Center in Romania of 347 Renal Transplant Patients Treated with Tacrolimus, Mycophenolate, and Steroids to Evaluate the Association Between Anti-HLA Antibodies and 5-Year Graft Survival

Ion Mărunţelu; Claudiu Eduard Nistor; Bogdan Mihai Cristea; Corina Andreea Rotarescu; Andreea Mirela Caragea; Maria Tizu; Ileana Constantinescu

doi:10.12659/AOT.937267

12 August 2022: Original Paper

Retrospective Study from a Single Center in Romania of 347 Renal Transplant Patients Treated with Tacrolimus, Mycophenolate, and Steroids to Evaluate the Association Between Anti-HLA Antibodies and 5-Year Graft Survival

Ion Mărunţelu ^12ABCDEF , Claudiu Eduard Nistor ^2CEF* , Bogdan Mihai Cristea ^2CE , Corina Andreea Rotarescu ^12BCD , Andreea Mirela Caragea ^2B , Maria Tizu ^2B , Ileana Constantinescu ^12AD

DOI: 10.12659/AOT.937267

Ann Transplant 2022; 27:e937267

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Background Material and Methods Results Discussion Conclusions References

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Table 6 Hazard ratios with 95% confidence interval in patients without preformed anti-HLA antibodies.

Factor	Negative HLA antibodies	Positive HLA antibodies
Negative HLA antibodies	–	4.0251
Negative HLA antibodies	–	1.5574 to 10.4032
Positive HLA antibodies	0.2484
Positive HLA antibodies	0.09612 to 0.6421
HLA – human leukocyte antigen. In the non-HLA previous sensitized group, the estimated relative risk of the event of kidney graft loss occurring in the subgroup with de novo anti-HLA antibodies is 4.0251 greater than in the subgroup with no HLA antibodies.

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Retrospective Study from a Single Center in Romania of 347 Renal Transplant Patients Treated with Tacrolimus, Mycophenolate, and Steroids to Evaluate the Association Between Anti-HLA Antibodies and 5-Year Graft Survival

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