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11 October 2022: Original Paper

Reduced Risk of Chronic Graft-Versus-Host Disease (cGVHD) by Rabbit Anti-Thymocyte Globulin (ATG) in Patients Undergoing Matched Sibling Donor Transplantation in Hematological Malignancies

Shu Fang 12ABCDEF* , Nan Wang 23ABCF* , Lili Wang 2ABCD* , Jishan Du 23BCF , Jingjing Yang 23BCF , Yanan Wen 23BCF , Yan Wei 23BCF , Kun Qian 12BCD , Hao Wang 23ABF , Yifan Jiao 23BCF , Chunji Gao 12ACEG* , Liping Dou 2ABDEG*

DOI: 10.12659/AOT.937356

Ann Transplant 2022; 27:e937356

Table 3 Univariate analysis of risk factors for grades 2–4 aGVHD and cGVHD in all patients.

Grades 2–4 aGVHDChronic GVHD
HR95% CIpHR95% CIp
ATG vs non-ATG1.5730.748–3.3070.2320.2220.093–0.5300.001
Recipient age (≥ median vs < median)0.9620.457–2.0210.9180.9300.427–2.0270.856
Donor age (≥ median vs < median)1.1400.542–2.3960.7301.0400.531–2.0390.908
Donor-recipient gender match
 Female to male vs others1.0910.493–2.4120.8300.7190.335–1.5420.397
Donor-recipient ABO match
 Mismatch vs match1.8580.885–3.9020.1011.1530.576–2.3080.688
Diagnosis (ALL vs others)1.2430.562–2.7480.5910.3960.153–1.0230.056
Time interval between diagnosis and HSCT
 ≥6 m vs1.8060.845–3.8590.1270.6790.344–1.3390.264
Cytogenetic risk
 High vs favorable/intermediate1.8540.868–3.9640.1110.3250.126–0.8430.021
Disease status at HSCT
 Untreated/refractory/relapsed vs CR0.5950.206–1.7150.3361.5310.692–3.3860.293
Disease risk index
 High/very high vs low/intermediate1.5560.728–3.3220.2540.3130.121–0.8100.017
MNC (≥ median vs < median)1.3150.622–2.7810.4730.5350.268–1.0680.076
CD34 (≥ median vs < median)2.0260.935–4.3910.0730.4740.234–0.9580.038
aGVHD (Grades 2–4 vs grades 0–1)0.8280.403–1.7040.608
ATG – anti-thymocyte globulin; aGVHD – acute graft-versus-host disease; GVHD – graft-versus-host disease; HSCT – hematopoietic stem cell transplantation; ALL – acute lymphoblastic leukemia; CR – complete remission; MNCs – mononuclear cells.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358