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11 October 2022: Original Paper

Reduced Risk of Chronic Graft-Versus-Host Disease (cGVHD) by Rabbit Anti-Thymocyte Globulin (ATG) in Patients Undergoing Matched Sibling Donor Transplantation in Hematological Malignancies

Shu Fang 12ABCDEF* , Nan Wang 23ABCF* , Lili Wang 2ABCD* , Jishan Du 23BCF , Jingjing Yang 23BCF , Yanan Wen 23BCF , Yan Wei 23BCF , Kun Qian 12BCD , Hao Wang 23ABF , Yifan Jiao 23BCF , Chunji Gao 12ACEG* , Liping Dou 2ABDEG*

DOI: 10.12659/AOT.937356

Ann Transplant 2022; 27:e937356

Table 4 Multivariate analysis of risk factors for transplant outcomes in all patients.

VariablesHR95% CIp
Grades 2–4 aGVHD
Donor-recipient ABO match
 Mismatch vs match1.9780.933–4.1920.075
Time interval between diagnosis and HSCT
 ≥6 m vs2.0320.943–4.3800.070
CD34 (≥ median vs < median)1.9760.911–4.2890.085
Chronic GVHD
 Diagnosis (ALL vs others)0.7910.288–2.1730.650
 ATG vs non-ATG0.2510.108–0.5820.001
Disease risk index
 High/very high vs low/intermediate0.4140.158–1.0830.072
Moderate to severe cGVHD
 ATG vs non-ATG0.3140.103–0.9580.042
 Recipient age (≥ median vs < median)0.4280.161–1.1430.090
Extensive cGVHD
 ATG vs non-ATG0.2690.073–0.9950.049
 Diagnosis (ALL vs others)1.5360.728–3.2410.260
 ATG vs non-ATG2.3371.133–4.8220.022
 Time interval between diagnosis and HSCT
  ≥6 m vs < 6 m0.5200.253–1.0710.076
 Disease risk index
  High/very high vs low/intermediate1.6540.979–2.7920.060
 CD34 (≥ median vs < median)1.7851.067–2.9840.027
 Time interval between diagnosis and HSCT
  ≥6 m vs0.5590.266–1.1760.125
 Time interval between diagnosis and HSCT
  ≥6 m vs0.5930.311–1.1330.114
ATG – anti-thymocyte globulin; aGVHD – acute graft-versus-host disease; cGVHD – chronic graft-versus-host disease; HSCT – hematopoietic stem cell transplantation; ALL – acute lymphoblastic leukemia; CR – complete remission; MNCs – mononuclear cells.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358