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11 October 2022: Original Paper

Reduced Risk of Chronic Graft-Versus-Host Disease (cGVHD) by Rabbit Anti-Thymocyte Globulin (ATG) in Patients Undergoing Matched Sibling Donor Transplantation in Hematological Malignancies

Shu Fang 12ABCDEF* , Nan Wang 23ABCF* , Lili Wang 2ABCD* , Jishan Du 23BCF , Jingjing Yang 23BCF , Yanan Wen 23BCF , Yan Wei 23BCF , Kun Qian 12BCD , Hao Wang 23ABF , Yifan Jiao 23BCF , Chunji Gao 12ACEG* , Liping Dou 2ABDEG*

DOI: 10.12659/AOT.937356

Ann Transplant 2022; 27:e937356

Supplementary Table 1 Univariate analysis of risk factors for GRFS in all patients.

VariablesHR95% CIp
ATG vs non-ATG1.2990.785–2.1490.309
Recipient age (≥ median vs < median)1.0540.636–1.7470.839
Donor age (≥ median vs < median)1.1550.698–1.9120.576
Donor-recipient gender match
 Female to male vs others1.1900.702–2.0200.518
Donor-recipient ABO match
 Mismatch vs match1.3360.798–2.2360.271
Diagnosis (ALL vs others)1.3330.779–2.2810.294
Time interval between diagnosis and HSCT
 ≥6 m vs0.9450.571–1.5630.826
Cytogenetic risk
 High vs favorable/intermediate1.6150.950–2.7450.076
Disease status at HSCT
 Untreated/refractory/relapsed vs CR0.8030.427–1.5120.498
Disease risk index
 High/very high vs low/intermediate1.7301.027–2.9130.039
MNC (≥ median vs < median)1.4070.848–2.3330.186
CD34 (≥ median vs < median)1.8461.107–3.0790.019
ATG – anti-thymocyte globulin; HSCT – hematopoietic stem cell transplantation; ALL – acute lymphoblastic leukemia; CR – complete remission; MNCs – mononuclear cells; GRFS – GVHD-free and relapse-free survival; GVHD – graft-versus-host disease.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358