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11 October 2022: Original Paper

Reduced Risk of Chronic Graft-Versus-Host Disease (cGVHD) by Rabbit Anti-Thymocyte Globulin (ATG) in Patients Undergoing Matched Sibling Donor Transplantation in Hematological Malignancies

Shu Fang 12ABCDEF* , Nan Wang 23ABCF* , Lili Wang 2ABCD* , Jishan Du 23BCF , Jingjing Yang 23BCF , Yanan Wen 23BCF , Yan Wei 23BCF , Kun Qian 12BCD , Hao Wang 23ABF , Yifan Jiao 23BCF , Chunji Gao 12ACEG* , Liping Dou 2ABDEG*

DOI: 10.12659/AOT.937356

Ann Transplant 2022; 27:e937356

Supplementary Table 2 Univariate analysis of risk factors for OS and DFS in all patients.

HR95% CIpHR95% CIp
ATG vs non-ATG0.6830.323–1.4440.3181.4110.749–2.6570.287
Recipient age (≥ median vs < median)1.3240.638–2.7510.4511.2140.641–2.2970.552
Donor age (≥ median vs < median)0.9920.485–2.0310.9831.1470.611–2.1550.669
Donor-recipient gender match
 Female to male vs others0.9090.416–1.9850.8100.9650.489–1.9050.918
Donor-recipient ABO match
 Mismatch vs match1.1960.575–2.4880.6311.4150.751–2.6670.283
Diagnosis (ALL vs others)0.9790.434–2.2050.9591.4630.749–2.8560.265
Time interval between diagnosis and HSCT
 ≥6 m vs0.5590.266–1.1760.1250.5930.311–1.1330.114
Cytogenetic risk
 High vs favorable/intermediate0.5930.243–1.4520.2531.1350.575–2.2420.715
Disease status at HSCT
 Untreated/refractory/relapsed vs CR1.3510.579–3.1510.4861.2620.599–2.6610.540
Disease risk index
 High/very high vs low/intermediate0.8210.366–1.8460.6341.3410.696–2.5830.381
MNC (≥ median vs0.8750.427–1.7940.7160.8810.469–1.6530.693
CD34 (≥ median vs1.0180.496–2.0920.9601.4020.742–2.6480.298
ATG – anti-thymocyte globulin; HSCT – hematopoietic stem cell transplantation; ALL – acute lymphoblastic leukemia; CR – complete remission; MNCs – mononuclear cells; OS – overall survival; DFS – disease-free survival.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358