04 November 2022: Original Paper
Revisiting the “Weekend Effect” on Adult and Pediatric Liver and Kidney Offer Acceptance
Takayuki Yamamoto ABCDEF* , Anushi Shah E , Mike Fruscione E , Shoko Kimura E , Nahel Elias E , Heidi Yeh E , Tatsuo Kawai E , James F. Markmann ADEGDOI: 10.12659/AOT.937825
Ann Transplant 2022; 27:e937825
Table 2 Characteristics of potential deceased liver donors for the initial offers (accept liver vs decline liver).
| Liver donors | Group A (n=45168) | Group B (n=4308) | ||||
|---|---|---|---|---|---|---|
| Initial Offer | Initial Offer | |||||
| Donor characteristics | Accept liver (n=41925) | Decline liver (n=3243) | P-value | Accept liver (n=4033) | Decline liver (n=275) | P-value |
| Age (mean±SD) yo | 43.1±5.2 | 48.1±4.7 | ** | 9.6±6.3 | 6.7±6.2 | ** |
| Age ≥60yo in Group A, | 16.3% | 24.5% | ** | 33.6% | 50.2% | ** |
| Gender (Male/Female) (% Male) | 24839/17086 (59.2%) | 1915/1328 (59.0%) | ** | 2583/1450 (64.0%) | 169/106 (61.5%) | 0.399 |
| Ethnicity | ||||||
| Hispanic/Non-Hispanic (% Hispanic) | 6378/35547 (15.2%) | 597/2646 (18.4%) | ** | 787/3246 (19.5%) | 56/219 (20.4%) | 0.753 |
| Race | ** | 0.068 | ||||
| White | 26546 (63.3%) | 2054 (63.3%) | 2205 (54.7%) | 137 (49.8%) | ||
| African American | 7426 (17.7%) | 411 (12.7%) | 874 (21.7%) | 62 (22.5%) | ||
| Hispanic | 6112 (14.6%) | 575 (17.7%) | 755 (18.7%) | 53 (19.3%) | ||
| Others | 1841 (4.4%) | 203 (6.3%) | 199 (4.9%) | 23 (8.4%) | ||
| Cause of death | ** | 0.004* | ||||
| Stroke | 12514 (29.8%) | 1119 (34.5%) | 176 (4.4%) | 13 (4.7%) | ||
| Head trauma | 10880 (26.0%) | 685 (21.1%) | 1863 (46.2%) | 98 (35.6%) | ||
| Anoxia | 17574 (41.9%) | 1368 (42.2%) | 1850 (45.9%) | 156 (56.7%) | ||
| Others | 957 (2.3%) | 71 (2.2%) | 144 (3.5%) | 8 (2.9%) | ||
| h/o Hypertension | 38.4% | 48.3% | ** | 0.6% | 1.5% | 0.109 |
| h/o Diabetes | 13.8% | 19.8% | ** | 1.1% | 1.5% | 0.558 |
| Alcohol use | 18.6% | 27.0% | ** | – | – | – |
| Tobacco use | 22.6% | 26.4% | ** | – | – | – |
| IV drug use | 15.00% | 14.50% | 0.454 | – | – | – |
| Terminal hematocrit (%) | 29.0±5.4 | 29.3±5.7 | 0.001* | 28.0±5.2 | 28.4±5.2 | 0.155 |
| Terminal pH | 7.40±0.07 | 7.39±0.08 | ** | 7.41±0.71 | 7.40±0.83 | 0.002* |
| Terminal high Na (≥160 mg/dL) | 7.7% | 6.4% | 0.008* | 7.5% | 4.4% | 0.055 |
| Terminal ALT(U/L) | 100.7±345.2 | 191.3±513.2 | ** | 93.7±223.2 | 190.4±430.6 | * |
| Terminal AST(U/L) | 97.1±361.5 | 210.6±693.1 | ** | 112.0±244.1 | 223.8±570.1 | ** |
| Terminal T-bil (mg/dL) | 0.90±0.97 | 1.33±1.90 | ** | 0.90±0.94 | 1.04±1.46 | 0.027* |
| GPT >500U/L | 3.20% | 8.10% | ** | 2.5% | 9.1% | ** |
| T-bil >10mg/dL | 0.11% | 0.62% | ** | 0.1% | 0.7% | 0.036* |
| BMI (kg/m) | 28.6±6.9 | 30.3±8.0 | ** | 20.6±5.3 | 19.4±5.4 | ** |
| BMI ≥30 kg/m | 34.8% | 44.7% | ** | 5.7% | 5.1% | 0.787 |
| Height (cm) | 171.3±10.2 | 170.5±10.3 | ** | 134.6±41.2 | 114.3±43.5 | ** |
| Cardiac arrest period (min) | 28.7±20.3 | 28.8±20.0 | 0.917 | 30.0±21.3 | 31.6±20.3 | 0.453 |
| Clinical infection | 76.8% | 76.8% | 0.999 | 76.2% | 75.3% | 0.713 |
| HBc-Abs | 6.0% | 9.7% | ** | 0.7% | 2.2% | 0.019* |
| HCV Abs | 10.2% | 15.1% | ** | 0.1% | 0% | >0.999 |
| Weekend (Sat/Sun) | 27.5% | 29.6% | 0.012* | 28.0% | 28.4% | 0.890 |
| * ** | ||||||