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22 November 2022: Original Paper

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipients with Hepatocellular Carcinoma

Gonzalo Sapisochin 1ADE** , Wei Chen Lee 2ABCDE , Dong Jin Joo 3ABD , Jae-Won Joh 4ABE , Koichiro Hata 56BCDE , Arvinder Singh Soin 7ACDE , Uday Kiran Veldandi 8ABCDEF , Shuhei Kaneko 9ACDE , Matthias Meier 10ACDEG , Denise Leclair 11DE , Gangadhar Sunkara 11CDEF , Long Bin Jeng 12AB**

DOI: 10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

Table 5 Kaplan-Meier estimates of the proportion of subjects free from HCC recurrence or death (ITT).

Time since LTEVR+rTAC N=56sTAC N=61
Cumulative incidence rateKM% estimation without eventCumulative incidence rateKM% estimation without event
nKM%(95% CI)nKM%(95% CI)
Week 4* 0100.0(100.0, 100.0)0100.0(100.0, 100.0)
Month 12296.3(91.3, 100.0)690.0(82.4, 97.6)
Month 24688.4(79.7, 97.2)886.6(77.9, 95.2)
Month 36688.4(79.7, 97.2)984.6(75.2, 93.9)
Month 48786.2(76.7, 95.8)984.6(75.2, 93.9)
Month 60786.2(76.7, 95.8)1082.5(72.6, 92.4)
* Day of randomization i.e., start point.
CI – confidence interval; EVR – everolimus; HCC – hepatic cell carcinoma; ITT – intent-to-treat; KM – Kaplan-Meier; LT – liver transplantation; n – number of patients with event; N – the total number of patients in the treatment group; rTAC – reduced dose tacrolimus; sTAC – standard dose tacrolimus.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358