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22 November 2022: Original Paper

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipients with Hepatocellular Carcinoma

Gonzalo Sapisochin 1ADE** , Wei Chen Lee 2ABCDE , Dong Jin Joo 3ABD , Jae-Won Joh 4ABE , Koichiro Hata 56BCDE , Arvinder Singh Soin 7ACDE , Uday Kiran Veldandi 8ABCDEF , Shuhei Kaneko 9ACDE , Matthias Meier 10ACDEG , Denise Leclair 11DE , Gangadhar Sunkara 11CDEF , Long Bin Jeng 12AB**

DOI: 10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

Table 6 Multivariate Cox regression analysis for time to HCC recurrence or death (ie, death by any cause or HCC recurrence, whichever occurred earlier; ITT population*).

ParameterHazard ratio (95% CI)P-value
Treatment: EVR+rTAC vs sTAC0.979 (0.323, 2.969)0.9702
Milan Criteria: within vs beyond0.252 (0.072, 0.881)0.0309
ESDCAT: non-HCC vs HCC1.119 (0.273, 4.596)0.8758
Donor sex: male vs female0.378 (0.123, 1.163)0.0897
Recipient sex: male vs female0.610 (0.153, 2.437)0.4840
Diabetes at baseline: yes vs no1.191 (0.377, 3.766)0.7659
MELD score: ≥15 vs ≤143.029 (0.957, 9.582)0.0594
Race: White vs Asian1.246 (0.319, 4.873)0.7515
Donor age (by 1 year)0.973 (0.921, 1.027)0.3224
Recipient age (by 1 year)0.924 (0.870, 0.982)0.0108
* Firth’s penalized maximum likelihood estimation was used.
The interpretation of this multivariate analysis needs to consider few HCC recurrences or deaths in the data (only 7 and 10 for EVR and sTAC), and imbalance of some background factors due to which widths of CI have become large for some parameters. CI – confidence interval; ESDCAT – end-stage disease condition at transplant; EVR – everolimus; HCC – hepatocellular carcinoma; ITT – intent-to-treat; MELD – model for end-stage liver disease; rTAC – reduced-dose tacrolimus; sTAC – standard-dose tacrolimus.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358