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22 November 2022: Original Paper

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipients with Hepatocellular Carcinoma

Gonzalo Sapisochin 1ADE** , Wei Chen Lee 2ABCDE , Dong Jin Joo 3ABD , Jae-Won Joh 4ABE , Koichiro Hata 56BCDE , Arvinder Singh Soin 7ACDE , Uday Kiran Veldandi 8ABCDEF , Shuhei Kaneko 9ACDE , Matthias Meier 10ACDEG , Denise Leclair 11DE , Gangadhar Sunkara 11CDEF , Long Bin Jeng 12AB**

DOI: 10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

Table 7 Safety events for the patients who entered in H2406 in the AT population.

AEs by PTEVR+rTAC N=39n (%)sTAC N=43n (%)
Subjects with at least one AE16 (41.0)23 (53.5)
Subjects with SAEs3 (7.7)6 (14.0)
AEs (≥3% in any group)
 Abdominal pain02 (4.7)
 Dental caries2 (5.1)1 (2.3)
 Diarrhea2 (5.1)0
 Nasopharyngitis1 (2.6)2 (4.7)
 Sinusitis02 (4.7)
 Upper respiratory tract infection1 (2.6)4 (9.3)
 Increased hepatic enzyme2 (5.1)0
 Osteoarthritis02 (4.7)
 Chronic kidney diseases02 (4.7)
 Cough02 (4.7)
Treatment-emergent AEs/infections were defined as any events starting on or after the first dose of immunosuppressant drug during the prospective period or before the last dose +7 days or events present prior to the start of the study but increased in severity after entering in this study. AE – adverse events; AT – as treated; EVR – everolimus; n – number of patients with events; N – the total number of patients in the treatment group; PT – preferred term; rTAC – reduced tacrolimus; SAE – serious adverse events; sTAC – standard dose tacrolimus.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358