13 December 2022: Original Paper
Hepatic Ischemia/Reperfusion Injury After Liver Transplantation Is Not Associated with Early Impairment of Left Ventricular Ejection Fraction
Zachary P. Rokop 1ABCDEF* , Kyle Frick 2ABDE , Joseph Zenisek 2ABDE , Elizabeth Kroepfl 3ABDE , Plamen Mihaylov 4ABDE , Kavish R. Patidar 5ABDE , Lauren Nephew 5ABDE , Richard S. Mangus 4ACDE , Chandrashekhar Kubal 4ABCDEGDOI: 10.12659/AOT.938105
Ann Transplant 2022; 27:e938105
Table 2 Preoperative and intraoperative recipient variables, stratified by severity of hepatic ischemia reperfusion injury (hIRI) as defined by: no hIRI: AST <200; mild hIRI: AST <2000, moderate hIRI: 2000 <AST <5000, severe hIRI: AST >5000. Values are reported as means and standard deviations unless otherwise specified. P values represent significance of pairwise comparison in relation to no hIRI group.
| No hIRIN=31 | Mild hIRIN=120 | Moderate hIRIN=15 | Severe hIRIN=7 | P value | |
|---|---|---|---|---|---|
| Age (median) (range) | 55 yr (29–71) | 58 yr (22–74) | 58 yr (35–67) | 53 yr (41–64) | ns |
| Sex | M: 20, F: 11 | M 74, F: 46 | M: 9, F: 6 | M: 3, F 4 | ns |
| MELD (SD) | 25.8 (7.9) | 23.2 (7.7) | 23.87 (8.4) | 18.3 (5.0)* | 0.009 |
| DCD organ | 2 (6.5%) | 27 (22.5%)* | 6 (40%)* | 4 (57.1%)* | |
| Warm ischemia time (minutes) (SD) | 21.22 (7.59) | 23.45 (10.2) | 24.7 (6.7) | 25.1 (7.4) | ns |
| Cold ischemia time (minutes) (SD) | 311.6 (101.8) | 279.6 (77.9) | 309.9 (99.3) | 309.3 (83.7) | ns |
| Intra-op pressor use (median, range) | |||||
| Epi, mcg | 0 (0–600) | 0 (0–2060) | 50 (0–400) | 57 (10–360)* | |
| Norepi, mg | 1.85 (0–158) | 1.2 (0–218.8) | 2.3 (0.5–4.3) | 4.4 (0.4–75)* | 0.004 |
| Vaso, units | 5.61 (0–31.6) | 7.65 (0–149) | 9.2 (0.7–35) | 19.5 (0–51)* | 0.03 |
| Phenyl, mcg | 600 (0–610) | 450 (0–3875) | 800 (0–1600) | 650 (100–1150) | ns |
| Graft steatosis | |||||
| None | 7 (22.6%) | 45 (37.5%) | 5 (33%) | 1 (14%) | ns |
| Mild | 14 (45.2%) | 44 (36.7%) | 6 (40%) | 4 (57%) | ns |
| Moderate | 3 (9.7%) | 13 (10.8%) | 3 (20%) | 2 (29%) | ns |
| Severe | 7 (22.6%) | 16 (7.5%) | 1 (7%) | 0 | ns |
| * ** *** ns – no significance. | |||||