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13 December 2022 : Original article  

Hepatic Ischemia/Reperfusion Injury After Liver Transplantation Is Not Associated with Early Impairment of Left Ventricular Ejection Fraction

Zachary P. Rokop1ABCDEF*, Kyle Frick2ABDE, Joseph Zenisek2ABDE, Elizabeth Kroepfl3ABDE, Plamen Mihaylov4ABDE, Kavish R. Patidar ORCID logo5ABDE, Lauren Nephew5ABDE, Richard S. Mangus ORCID logo4ACDE, Chandrashekhar Kubal4ABCDEG

DOI: 10.12659/AOT.938105

Ann Transplant 2022; 27:e938105

Table 2 Preoperative and intraoperative recipient variables, stratified by severity of hepatic ischemia reperfusion injury (hIRI) as defined by: no hIRI: AST <200; mild hIRI: AST <2000, moderate hIRI: 2000 <AST <5000, severe hIRI: AST >5000. Values are reported as means and standard deviations unless otherwise specified. P values represent significance of pairwise comparison in relation to no hIRI group.

No hIRIN=31Mild hIRIN=120Moderate hIRIN=15Severe hIRIN=7P value
Age (median) (range)55 yr (29–71)58 yr (22–74)58 yr (35–67)53 yr (41–64)ns
SexM: 20, F: 11M 74, F: 46M: 9, F: 6M: 3, F 4ns
MELD (SD)25.8 (7.9)23.2 (7.7)23.87 (8.4)18.3 (5.0)* 0.009
DCD organ2 (6.5%)27 (22.5%)* 6 (40%)* 4 (57.1%)*
Warm ischemia time (minutes) (SD)21.22 (7.59)23.45 (10.2)24.7 (6.7)25.1 (7.4)ns
Cold ischemia time (minutes) (SD)311.6 (101.8)279.6 (77.9)309.9 (99.3)309.3 (83.7)ns
Intra-op pressor use (median, range)
 Epi, mcg0 (0–600)0 (0–2060)50 (0–400)57 (10–360)*
 Norepi, mg1.85 (0–158)1.2 (0–218.8)2.3 (0.5–4.3)4.4 (0.4–75)* 0.004
 Vaso, units5.61 (0–31.6)7.65 (0–149)9.2 (0.7–35)19.5 (0–51)* 0.03
 Phenyl, mcg600 (0–610)450 (0–3875)800 (0–1600)650 (100–1150)ns
Graft steatosis
 None7 (22.6%)45 (37.5%)5 (33%)1 (14%)ns
 Mild14 (45.2%)44 (36.7%)6 (40%)4 (57%)ns
 Moderate3 (9.7%)13 (10.8%)3 (20%)2 (29%)ns
 Severe7 (22.6%)16 (7.5%)1 (7%)0ns
ns – no significance.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358