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13 December 2022: Original Paper

Hepatic Ischemia/Reperfusion Injury After Liver Transplantation Is Not Associated with Early Impairment of Left Ventricular Ejection Fraction

Zachary P. Rokop 1ABCDEF* , Kyle Frick 2ABDE , Joseph Zenisek 2ABDE , Elizabeth Kroepfl 3ABDE , Plamen Mihaylov 4ABDE , Kavish R. Patidar 5ABDE , Lauren Nephew 5ABDE , Richard S. Mangus 4ACDE , Chandrashekhar Kubal 4ABCDEG

DOI: 10.12659/AOT.938105

Ann Transplant 2022; 27:e938105

Table 3 Post-liver transplant outcomes stratified by severity of hepatic ischemia reperfusion injury (hIRI) as defined by: no hIRI: AST <200; mild hIRI: AST <2000, moderate hIRI: 2000 <AST <5000, severe hIRI: AST >5000. Values are reported as means and standard deviations unless otherwise specified.

No hIRIN=31Mild hIRIN=120Moderate hIRIN=15Severe hIRIN=7P value
Graft Loss06 (5%)1 (6%)1 (14%)ns
Patient Death06 (5%)1 (6%)0ns
Pre-LT LVEF (%) (SD)66.6 (5.9)63.7 (6.5)66.9 (6.1)67.4 (7.1)ns
Post-LT LVEF (%) (SD)62.23 (11.4)64.0 (7.7)64.9 (5.6)67.7 (5.6)ns
Pressors at time of Echo13 (41.9%)47 (31%)2 (13.3%)3 (42.9%)ns
Post-LT LVEF1 (3.2%)2 (1.7%)00ns
POD 1 BNP (pg/ml) (SD)474.8 (612.1)276 (306.5)208 (160.3)94 (57.5)ns
ns – no significance.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358