13 December 2022 : Original article
Hepatic Ischemia/Reperfusion Injury After Liver Transplantation Is Not Associated with Early Impairment of Left Ventricular Ejection Fraction
Zachary P. Rokop1ABCDEF*, Kyle Frick2ABDE, Joseph Zenisek2ABDE, Elizabeth Kroepfl3ABDE, Plamen Mihaylov4ABDE, Kavish R. Patidar
5ABDE, Lauren Nephew5ABDE, Richard S. Mangus 4ACDE, Chandrashekhar Kubal4ABCDEG
DOI: 10.12659/AOT.938105
Ann Transplant 2022; 27:e938105
Table 3 Post-liver transplant outcomes stratified by severity of hepatic ischemia reperfusion injury (hIRI) as defined by: no hIRI: AST <200; mild hIRI: AST <2000, moderate hIRI: 2000 <AST <5000, severe hIRI: AST >5000. Values are reported as means and standard deviations unless otherwise specified.
| No hIRIN=31 | Mild hIRIN=120 | Moderate hIRIN=15 | Severe hIRIN=7 | P value | |
|---|---|---|---|---|---|
| Graft Loss | 0 | 6 (5%) | 1 (6%) | 1 (14%) | ns |
| Patient Death | 0 | 6 (5%) | 1 (6%) | 0 | ns |
| Pre-LT LVEF (%) (SD) | 66.6 (5.9) | 63.7 (6.5) | 66.9 (6.1) | 67.4 (7.1) | ns |
| Post-LT LVEF (%) (SD) | 62.23 (11.4) | 64.0 (7.7) | 64.9 (5.6) | 67.7 (5.6) | ns |
| Pressors at time of Echo | 13 (41.9%) | 47 (31%) | 2 (13.3%) | 3 (42.9%) | ns |
| Post-LT LVEF <35% (patients) | 1 (3.2%) | 2 (1.7%) | 0 | 0 | ns |
| POD 1 BNP (pg/ml) (SD) | 474.8 (612.1) | 276 (306.5) | 208 (160.3) | 94 (57.5) | ns |
| ns – no significance. | |||||