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21 April 2023: Original Paper

Converting from Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in Patients with Hepatitis B Following Liver Transplantation

Chih-Hsien Cheng ABCDE , Hao-Chien Hung BC , Jin-Chiao Lee BC , Yu-Chao Wang CD , Tsung-Han Wu CD , Chen-Fang Lee ABC , Ting-Jung Wu BC , Hong-Shiue Chou BC , Kun-Ming Chan BC , Wei-Chen Lee ABCD*

DOI: 10.12659/AOT.938731

Ann Transplant 2023; 28:e938731

Table 1 Patient characteristics.

Age (years), median (range)54 (35–67)
Sex, male/female, n15/2
MELD, median (IQR)19 (9–27)
Indication for transplantation, n (%)
 Hepatic failure5 (29.4)
 Complications of liver cirrhosis4 (23.5)
 HCC8 (47)
Pre-transplant comorbidity, n (%)
 HTN4 (23.5)
 DM3 (17.6)
Type of transplant, n (%)
 LDLT10 (58.8)
 DDLT4 (23.5)
 SLT3 (17.7)
HBeAg positive, n (%)4 (23.5)
Quantitative HBsAg (IU/ml), median (IQR)243 (43–153332)
HBV DNA (IU/ml), median (IQR)182 (20–68330000)
HCV coinfection, n (%)1 (5.9)
Duration of TDF treatment (days), median (range)1137 (579–1639)
HBsAg persistence, n (%)7 (41.1)
HBV recurrence, n (%)6 (35.3)
Therapy, naïve/with previous therapy/switch after recurrence, n6/5/6
MELD – Model For End-Stage Liver Disease; HCC – hepatocellular carcinoma; HTN – hypertension; DM – diabetes mellitus; LDLT – living donor liver transplantation; DDLT – deceased donor liver transplantation; SLT – split liver transplantation; IQR – interquartile range; HBeAg – hepatitis B e antigen; HBsAg – hepatitis B surface antigen; HBV – hepatitis B virus; HCV – hepatitis C virus; HCC – hepatocellular carcinoma; TDF – tenofovir disoproxil fumarate.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358