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21 April 2023 : Original article  

Converting from Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in Patients with Hepatitis B Following Liver Transplantation

Chih-Hsien Cheng1ABCDE*, Hao-Chien Hung1BC, Jin-Chiao Lee1BC, Yu-Chao Wang1CD, Tsung-Han Wu1CD, Chen-Fang Lee1ABC, Ting-Jung Wu1BC, Hong-Shiue Chou1BC, Kun-Ming Chan ORCID logo1BC, Wei-Chen Lee1ABCD

DOI: 10.12659/AOT.938731

Ann Transplant 2023; 28:e938731

Table 2 Patients with HBV recurrence.

PatientTime to recurrence (years)Post-transplant antiviral therapyAntiviral therapy after HBV recurrenceHBV DNA at recurrence (IU/ml)YIDD mutationHBsAg declineHBsAg prezent (IU/ml)HBV DNA AT prezent (IUI/ml)CKD stage before TDFCKD stage before TAF
56LAM+ADVLAM+TDFUndetec-tableNoUndetec-tableUndetec-table22
62ETVETV+TDF59.6×10NoUndetec-tableUndetec-table3a4
912LAM+ADVLAM+TDF1.7×10Yesseq 552No48Undetec-table22
1215LAMTDF68.3×10NoUndetec-table22
156LAM+ADVTDF2115Yesseq 55256Undetec-table11
162ETV+ADVETV+TDFUndetec-tableNoNo142Undetec-table11
HBV – hepatitis B virus; LAM – lamivudine; ADV – adefovir; ETV – entecavir; TBV – telbivudine; TDF – tenofovir disoproxil fumarate; TAF – tenofovir alafenamide; CKD – chronic kidney disease; Seq – sequence.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358