09 January 2024 : Original article
Retrospective Analysis of the Impact of High- and Low-Quality Donor Livers for Patients with High-Acuity Illness
Ron K. Varghese
1ABCDEFG*, Greta E. Handing 2ABCDFG, Ashley E. Montgomery 2ADE, Abbas A. Rana 3ACDE, John A. Goss 3AD
DOI: 10.12659/AOT.941931
Ann Transplant 2024; 29:e941931
Table 2 Donor and recipient risk factors considered in analyses.
| Donor risk factors | Recipient risk factors |
|---|---|
| High-quality donor (DRI <1.33) | Age 18–30 |
| Low-quality donor (DRI >1.86) | Age 60–65 |
| ALT/SPGT 60–100 u/L | Age >65 |
| ALT/SPGT >100 u/L | Albumin 0.1–2.0 g/dL |
| AST/SGOT 90–140 u/L | Ascites at transplant |
| AST/SGOT >140 u/L | African American Recipient |
| Creatinine 1.5–2.0 mg/dL | BMI 30–35 |
| Creatine >2.0 mg/dL | BMI 35–40 |
| Donor pH 7.1–7.2 | BMI >40 |
| Donor pH 7.0–7.1 | Functional status 10% |
| Donor pH <7.0 | Functional status 20% |
| Hepatitus C serology | Functional status 30% |
| Height Difference of 30–60 cm | Functional status 40% |
| Height difference of >60 cm | Functional status 50% |
| Height difference of −30–60 cm | Functional status 60% |
| Height difference of >−60 cm | Functional status 70% |
| Total bilirubin 1.0–1.8 mg/dL | Functional status 80% |
| Total bilirubin > 1.8 mg/dL | Functional status 90% |
| Weight difference 45–70 lbs | Functional status 100% |
| Weight difference >70 lbs | No education/dropout |
| Weight difference −70–45 lbs | Technical degree |
| Weight difference >−70 lbs | Bachelor’s degree |
| Warm ischemic time < 15 minutes | Doctorate degree |
| Warm ischemic time 15–30 minutes | Occupation |
| Warm ischemic time >30 minutes | Cirrhosis |
| Alcoholic cirrhosis | |
| Hepatitis C | |
| Encephalopathy | |
| Hepatocellular carcinoma | |
| Hemodialysis prior to transplant | |
| Spontaneous bacterial peritonitis | |
| Incompatible blood type | |
| INR 2.0–2.5 | |
| INR 2.5–3.0 | |
| INR 3.0–3.5 | |
| INR 3.5–4.0 | |
| INR > 4.0 | |
| Serum sodium <125 mEq/L | |
| Serum sodium 125–130 mEq/L | |
| Serum sodium 130–135 mEq/L | |
| Serum sodium 150–200 mEq/L | |
| History of portal vein thrombosis at registration | |
| History of portal vein thrombosis at transplant | |
| Hospitalized not in ICU pre-transplant | |
| In ICU pre-transplant | |
| Life support | |
| On ventilator at transplant | |
| Medicaid | |
| Private insurance | |
| Previous abdominal surgery | |
| Transjugular intrahepatic portacaval stint shunt at transplant | |
| Total bilirubin <2 mg/dL | |
| Total bilirubin 8–16 mg/dL | |
| Total bilirubin 16–32 mg/dL | |
| Total bilirubin >32 mg/dL | |
| Region: CT, ME, MA, NH, RI | |
| Region: DE, DC, MD, NJ, PA, N. VA, WV | |
| Region: AL, AR, FL, GA, LA, MS, PR | |
| Region: OK, TX | |
| Region: AZ, CA, NV, NM, UT | |
| Region: AK, HI, ID, MT, OR, WA | |
| Region: IL, MN, ND, SD, WI | |
| Region: CO, IA, KS, MO, NE, WY | |
| Region: NY, VT | |
| Region: IN, MI, OH | |
| Region: KY, NC, SC, TN, VA |