19 March 2024 : Original article
Long-Term Outcomes with Prolonged-Release Tacrolimus in Kidney Transplantation: A Retrospective Real-World Data Analysis
Wilfried Gwinner1ABDE*, Swapneel Anaokar2ACDE, Martin Blogg2ACDE, Birgit Hermann3ACDE, Carola del Pilar Repetur2CDE, Mario Schiffer4ABDEDOI: 10.12659/AOT.942167
Ann Transplant 2024; 29:e942167
Table 7 Multivariable analysis of independent variables associated with the primary composite endpoint for all patients.
| Parameter | Hazard ratio* (95% CI) | P value | Univariate hazard ratio** (95% CI) |
|---|---|---|---|
| Transplant center | |||
| Center 2 vs 1 | 0.196 (0.078–0.494) | <0.001 | 0.372 (0.232–0.596) |
| Patient race/ethnicity | |||
| Black/African-American/Caribbean vs Caucasian | 2.389 (0.487–11.715) | 0.283 | 1.807 (0.435–7.503) |
| Middle Eastern vs Caucasian | 13.519 (1.257–145.392) | 0.032 | 1.647 (0.226–12.007) |
| Other vs Caucasian | 6.048 (0.784–46.635) | 0.084 | 3.760 (0.904–15.648) |
| Not available vs Caucasian | 0.96 (0.45–2.048) | 0.916 | 2.621 (1.641–4.187) |
| No. previous transplants | |||
| 1 vs 0 | 6.592 (2.331–18.639) | <0.001 | 2.286 (1.047–4.990) |
| 2 vs 0 | 0.000 (0.000-NE) | 0.994 | 0.000 (0.000–0.000) |
| Donor SCD/ECD status | |||
| ECD vs SCD | 2.931 (1.554–5.526) | <0.001 | 3.500 (2.158–5.677) |
| Not available vs SCD | 0.394 (0.134–1.158) | 0.090 | 0.883 (0.409–1.907) |
| Best eGFR, (mL/min/1.73 m)*** | 0.933 (0.894–0.974)## | 0.001 | 0.950 (0.929–0.971) |
| Best serum creatinine (mg/dL)*** | 0.892 (0.474–1.680)## | 0.724 | 2.024 (1.539–2.662) |
| CI – confidence interval; ECD – expanded criteria donor; eGFR – estimated glomerular filtration rate; NE – not estimable; SCD – standard criteria donor. Proportional hazards were assumed, hazard ratio * Hazard ratio generated through multivariate analysis; variables were selected using a forward selection model ( value threshold 0.05); eligible for model entry were all variables with a value of ** Hazard ratio based on univariate Cox regression model including the parameter as the only covariate. *** 8–12 weeks after transplant. # Estimated using modification of diet in renal disease-4 (MDRD-4) method. ## Hazard ratio stated in relation to increases/decreases of 1 mL. | |||