19 December 2023>: Original Paper
Allogeneic Hematopoietic Stem Cell Transplantation Can Improve Prognosis of Extramedullary Infiltration Positive t(8;21) Acute Myeloid Leukemia
Xiaokai Wang 1BCDEF* , Xuetong Xu 2BCDF* , Hao Zhang 3CDF* , Wei Zhou 45BC , Dan Gong 6BD , Chengying Zhu 78CF , Dejun Zhou 9ADFG* , Guofeng Chen 9ABCDEFG*DOI: 10.12659/AOT.942197
Ann Transplant 2023; 28:e942197
Table 2 Univariable models of pOS in t(8;21) AML patients with EMI at diagnosis.
HR (95% CI) | P-value | |
---|---|---|
Allo-HSCT | ||
No | 1.0 | |
Yes | 0.37 (0.16, 0.86) | 0.0202 |
Age, years | ||
≤14 | 1.0 | |
≥15 | 1.73 (0.72, 4.19) | 0.2223 |
Sex | ||
Male | 1.0 | |
Female | 0.88 (0.43, 1.80) | 0.7225 |
WBC above median, ×10/L | ||
≤20 | 1.0 | |
>20 | 0.80 (0.40, 1.57) | 0.5112 |
HB above median, g/L | ||
≤100 | 1.0 | |
>100 | 1.31 (0.66, 2.57) | 0.4419 |
PLT above median, ×10/L | ||
≤20 | 1.0 | |
>20 | 0.87 (0.44, 1.71) | 0.6761 |
Blasts in BM above median, % | ||
≤60 | 1.0 | |
>60 | 1.36 (0.69, 2.68) | 0.3675 |
Numbers of additional abnormal karyotype | ||
0 | 1.0 | |
1 | 2.49 (1.09, 5.68) | 0.0301 |
2 | 1.55 (0.34, 7.00) | 0.5707 |
≥3 | 3.52 (0.43, 28.74) | 0.2393 |
Type of karyotype | ||
t(8;21)-only | 1.0 | |
Additional -Y | 2.66 (1.01, 7.02) | 0.0477 |
additional -X | 2.00 (0.56, 7.21) | 0.2877 |
Additional other abnormal karyotype | 2.73 (0.73, 10.21) | 0.1343 |
Complex karyotype* | 1.90 (0.52, 6.85) | 0.3290 |
KIT mutation | ||
Negative | 1.0 | |
Positive | 0.87 (0.39, 1.95) | 0.7306 |
WT1 | ||
Negative | 1.0 | |
Positive | 1.94 (0.85, 4.42) | 0.1172 |
FLT3-ITD | ||
Negative | 1.0 | |
Positive | 0.82 (0.11, 6.07) | 0.8487 |
* Complex karyotype was defined as ≥3 clonal chromosomal abnormalities. pOS – probability of overall survival; EMI – extramedullary infiltration; HR – hazard ratio; allo-HSCT – allogeneic hematopoietic stem cell transplantation; WBC – white blood cell count; HB – hemoglobin; PLT – platelets; BM – bone marrow; -Y – loss of Y chromosome; -X – loss of X chromosome. |