06 February 2024>: Original Paper
Immunoprotective Effect of Liver Allograft on Patients with Combined Liver and Kidney Transplantation
Joon-Young Kim 1BCDEF* , Hye Bin Kim 2BCDEF* , Jin-Myung Kim 1BCD , Hye Eun Kwon 1BCD , Young Hoon Kim 1BCD , Youngmin Ko 1BCD , Frances S. Sung 1BCD , Joo Hee Jung 1BC , Chung Hee Baek 3B , Hyosang Kim 3B , Su-Kil Park 3B , Sung Shin 1BCD , Hyunwook Kwon 1ABCDEF*DOI: 10.12659/AOT.942763
Ann Transplant 2024; 29:e942763
Table 1 Baseline and clinical characteristics of the study patients.
Total | KT | LTKT | P-value | |
---|---|---|---|---|
Number of patients | 4312 (100) | 4268 (99.0) | 44 (1.0) | – |
Mean age (years) | 47.0±12.4 | 47.0±12.4 | 40.2±8.2 | 0.090 |
Female sex | 1814 (42.1) | 1807 (42.3) | 7 (15.9) | |
Diabetes mellitus | 1034 (24.0) | 1018 (23.9) | 16 (36.4) | 0.053 |
Hypertension | 3637 (84.3) | 3605 (84.5) | 32 (72.7) | 0.033 |
Hepatitis B virus | 144 (3.3) | 132 (3.1) | 12 (27.3) | |
Hepatitis C virus | 79 (1.8) | 78 (1.8) | 1 (2.3) | 0.827 |
Body mass index, Kg/m | 23.4±39.9 | 23.4±40.1 | 22.0±2.7 | 0.819 |
ABO incompatible | 735 (14.6) | 730 (14.6) | 5 (11.4) | 0.542 |
FCXM positive | 261 (6.1) | 259 (6.1) | 2 (4.5) | 0.673 |
HLA-A, B, DR mismatch | 3.2±1.7 | 3.2±1.7 | 3.5±1.9 | 0.168 |
PRA class I | 13.4±25.8 | 13.1±25.8 | 11.3±24.2 | 0.627 |
PRA class II | 15.2±27.6 | 15.2±27.6 | 13.4±26.7 | 0.773 |
Cadaveric donor | 857 (19.9) | 844 (19.8) | 13 (29.5) | 0.106 |
Living donor | 3455 (80.1) | 3424 (80.2) | 31 (70.5) | |
Calcineurin inhibitor | 0.924 | |||
Tacrolimus | 3306 (76.7) | 3272 (76.7) | 34 (77.3) | |
Cyclosporin | 1006 (23.3) | 996 (23.3) | 10 (22.7) | |
Induction | 0.29 | |||
Basiliximab | 3919 (90.9) | 3877 (90.9) | 42 (95.5) | |
Anti-thymocyte globulin | 391 (9.1) | 389 (9.1) | 2 (4.5) | |
SLKT | 11 (25.0) | – | ||
KT after LT | 33 (75.0) | |||
Continuous data are presented as means±standard deviations. Categorical data are presented as a number (%).KT – kidney transplantation; LT – liver transplantation; FCXM – flow cytometry crossmatch; DSA – donor-specific antibody; PRA – panel reactive antibody; SLKT – simultaneous liver-kidney transplantation. |