30 April 2024 : Original article
Does Antibiotic Use Increase the Risk of Post-Transplantation Diabetes Mellitus? A Retrospective Study of Renal Transplant Patients
Zhenwei Jiang1BCDEF, Caomei Xu1CE, Huan Hou2C, Xuping Yang1D, Minyan Qian1B, Lian Zuo1B, Peipei Wang3B, Qing Qian1D, Yan Jiang1B, Nan Hu1AG*DOI: 10.12659/AOT.943282
Ann Transplant 2024; 29:e943282
Table 2 Influence of CYP3A5*3, POR*28, ABCB1 (3435 C>T), and ABCB1 (1236 C>T) polymorphisms on PTDM.
| SNP | PTDM, n (%) | Non-PTDM, n (%) | P value |
|---|---|---|---|
| CYP3A5*3 (6986 A>G) | 0.740 | ||
| A/A | 2 (6.9) | 37 (11.2) | |
| A/G | 11 (37.9) | 128 (38.8) | |
| G/G | 16 (55.2) | 165 (50.0) | |
| POR*28 (C>T) | 0.832 | ||
| C/C | 5 (17.2) | 70 (21.2) | |
| C/T | 21 (72.4) | 221 (67.0) | |
| T/T | 3 (17.3) | 39 (11.8) | |
| ABCB1 (3435 C>T) | 0.925 | ||
| C/C | 11 (37.9) | 117 (35.5) | |
| C/T | 14 (48.3) | 159 (48.2) | |
| T/T | 4 (13.8) | 54 (16.4) | |
| ABCB1 (1236 C>T) | 0.522 | ||
| C/C | 5 (17.2) | 43 (13.0) | |
| C/T | 14 (48.3) | 138 (41.8) | |
| T/T | 10 (34.5) | 149 (45.2) | |
| SNP – single-nucleotide polymorphism. Values are expressed as numbers (%). Categorical variables were analyzed by the chi-square test. | |||