30 April 2024 : Original article
Does Antibiotic Use Increase the Risk of Post-Transplantation Diabetes Mellitus? A Retrospective Study of Renal Transplant Patients
Zhenwei Jiang1BCDEF, Caomei Xu1CE, Huan Hou2C, Xuping Yang1D, Minyan Qian1B, Lian Zuo1B, Peipei Wang3B, Qing Qian1D, Yan Jiang1B, Nan Hu1AG*DOI: 10.12659/AOT.943282
Ann Transplant 2024; 29:e943282
Table 4 Logistic regression analysis of risk factors for PTDM.
| Variable | Univariable | Multivariable | ||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Age | 1.064 (1.027–1.104) | 0.001 | 1.049 (1.009–1.086) | 0.014 |
| BMI | 1.188 (1.068–1.323) | 0.002 | 1.178 (1.046–1.325) | 0.007 |
| TAC C at 7 days | 1.080 (1.005–1.160) | 0.035 | 1.045 (0.904–1.209) | 0.550 |
| TAC C/D at 7 days | 1.582 (1.025–2.441) | 0.038 | 1.159 (1.005–1.137) | 0.042 |
| TAC C at 14 days | 1.090 (1.002–1.186) | 0.045 | 1.100 (0.954–1.269) | 0.188 |
| TAC C at 28 days | 1.149 (0.999–1.320) | 0.051 | 1.094 (1.003–1.193) | 0.042 |
| Numbers of antibiotic use | 1.307 (1.101–1.553) | 0.002 | 1.004 (0.735–1.372) | 0.980 |
| Days of antibiotic use | 1.032 (1.003–1.063) | 0.032 | 1.007 (0.972–1.044) | 0.702 |
| Imipenem | 2.386 (1.204–4.730) | 0.013 | 1.970 (0.958–4.052) | 0.065 |
| Levofloxacin | 7.006 (2.388–20.560) | < 0.001 | 5.975 (1.845–19.345) | 0.003 |
| BMI – body mass index; OR: odds ratio; 95% CI – 95% confidence interval. The days of TAC C and C/D at different time points were calculated from the day after transplantation. | ||||