Clonal Hematopoiesis-Associated Gene Mutations Affect Acute Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation in AML Patients

Xiaoxuan Wei; Sai Huang; Zhenyang Gu; Jing Liu; Meng Li; Xiangshu Jin; Jian Bo; Fei Li; Yu Jing; Xiaoning Gao; Liping Dou; Daihong Liu; Chunji Gao

doi:10.12659/AOT.943688

02 July 2024 : Original article

Clonal Hematopoiesis-Associated Gene Mutations Affect Acute Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation in AML Patients

Xiaoxuan Wei^12ABCDEF, Sai Huang^1ABF, Zhenyang Gu^1ADEF, Jing Liu^1ADEF, Meng Li^1AF, Xiangshu Jin^1AF, Jian Bo^1AF, Fei Li^1A, Yu Jing^1A, Xiaoning Gao^1A, Liping Dou^1AB, Daihong Liu^1A, Chunji Gao^1ADEF*

DOI: 10.12659/AOT.943688

Ann Transplant 2024; 29:e943688

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Table 3 DNMT3A but not TET2 or ASXL1 mutation was associated with increased risk of aGVHD in patients over 45 years old.

	Allo-HSCT, ≥45 years old			Haplo-HSCT			Haplo-HSCT, ≥45 years old
	No aGVHD	aGVHD	P	No aGVHD	aGVHD	P	No aGVHD	aGVHD	P
CH mutations			0.320			0.049			0.184
No	14	12		22	38		8	6
Yes	17	26		13	50		9	19
DTA mutations			0.048			0.062			0.010
No	22	18		29	58		13	9
Yes	9	20		6	30		4	16
Mutated DNMT3A			0.042			0.139^*			0.026
No^a	22	18		29	58		13	9
Yes^b	4	12		2	14		2	9
Mutated TET2			0.652^*						0.096^*
No^a	22	18					13	9
Yes^c	2	3					0	3
Mutated ASXL1			0.187^*						0.165^*
No^a	22	18					13	9
Yes^d	1	4					1	4
Mutated TET2 or ASXL1			0.300						0.113^*
No^a	22	18					13	9
Yes^e	5	8					2	7
^* Represents the results from Fisher’s exact tests. ^a Patients without DTA mutation; ^b patients with DNMT3A mutation but not the other 2 mutations; ^c patients with TET2 mutation but not the other 2 mutations’ ^d patients with ASXL1 mutation but not the other 2 mutations; ^e patients with TET2 or ASXL1 mutations but no DNMT3A mutation. Allo-HSCT – allogeneic hematopoietic stem cell transplantation; haplo-HSCT – haploidentical hematopoietic stem cell transplantation; aGVHD – acute graft versus host disease; CH mutations – clonal hematopoiesis-associated mutation; DTA mutations – mutated DNMT3A, TET2, or ASXL1.

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Clonal Hematopoiesis-Associated Gene Mutations Affect Acute Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation in AML Patients

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