Clonal Hematopoiesis-Associated Gene Mutations Affect Acute Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation in AML Patients

Xiaoxuan Wei; Sai Huang; Zhenyang Gu; Jing Liu; Meng Li; Xiangshu Jin; Jian Bo; Fei Li; Yu Jing; Xiaoning Gao; Liping Dou; Daihong Liu; Chunji Gao

doi:10.12659/AOT.943688

02 July 2024 : Original article

Clonal Hematopoiesis-Associated Gene Mutations Affect Acute Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation in AML Patients

Xiaoxuan Wei^12ABCDEF, Sai Huang^1ABF, Zhenyang Gu^1ADEF, Jing Liu^1ADEF, Meng Li^1AF, Xiangshu Jin^1AF, Jian Bo^1AF, Fei Li^1A, Yu Jing^1A, Xiaoning Gao^1A, Liping Dou^1AB, Daihong Liu^1A, Chunji Gao^1ADEF*

DOI: 10.12659/AOT.943688

Ann Transplant 2024; 29:e943688

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Table 4 The risk of aGVHD.

	Grade II–IV aGVHD			Grade III–IV aGVHD
	No	Yes	P	No	Yes	P

CH mutations			0.056			0.835
No	22	39		54	7
Yes	13	50		55	8
DTA mutations			0.067			0.367^*
No	29	59		79	9
Yes	6	30		30	6

CH mutations			0.143			0.395
No	46	57		89	14
Yes	32	61		84	9
DTA mutations			0.348			0.823
No	59	82		124	17
Yes	19	36		49	6
, ≥
CH mutations			0.120			0.692^*
No	8	6		12	2
Yes	9	19		21	7
DTA mutations			0.010			0.268^*
No	13	9		19	3
Yes	4	16		14	6
, ≥
CH mutations			0.247			0.535^*
No	14	12		20	6
Yes	17	26		36	7
DTA mutations			0.048			0.738
No	22	18		33	7
Yes	9	20		23	6
^* Represents the results from Fisher’s exact tests. Allo-HSCT – allogeneic hematopoietic stem cell transplantation; haplo-HSCT – haploidentical hematopoietic stem cell transplantation; aGVHD – acute graft versus host disease; CH mutations – clonal hematopoiesis-associated mutation; DTA mutations – mutated DNMT3A, TET2, or ASXL1.

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Clonal Hematopoiesis-Associated Gene Mutations Affect Acute Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation in AML Patients

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