Clonal Hematopoiesis-Associated Gene Mutations Affect Acute Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation in AML Patients

Xiaoxuan Wei; Sai Huang; Zhenyang Gu; Jing Liu; Meng Li; Xiangshu Jin; Jian Bo; Fei Li; Yu Jing; Xiaoning Gao; Liping Dou; Daihong Liu; Chunji Gao

doi:10.12659/AOT.943688

02 July 2024 : Original article

Clonal Hematopoiesis-Associated Gene Mutations Affect Acute Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation in AML Patients

Xiaoxuan Wei^12ABCDEF, Sai Huang^1ABF, Zhenyang Gu^1ADEF, Jing Liu^1ADEF, Meng Li^1AF, Xiangshu Jin^1AF, Jian Bo^1AF, Fei Li^1A, Yu Jing^1A, Xiaoning Gao^1A, Liping Dou^1AB, Daihong Liu^1A, Chunji Gao^1ADEF*

DOI: 10.12659/AOT.943688

Ann Transplant 2024; 29:e943688

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Table 5 Univariate and Multivariate analysis of the association of various clinical features with aGVHD in patients receiving haplo-HSCT.

	Univariate analysis			Multivariate analysis
	OR	95% CI	P	OR	95% CI	P

Age (y)	0.975	0.944–1.007	0.129	0.952	0.912–0.994	0.026
Disease status at transplantation (non-CR vs CR)	1.448	0.491–4.275	0.502
Complex karyotypes (yes vs no)	0.274	0.058–1.292	0.102	0.144	0.020–1.069	0.058
Bone marrow blasts (%)	1.015	0.998–1.034	0.092	1.009	0.988–1.030	0.395
CH mutations (yes vs no)	2.227	0.995–4.981	0.051	1.842	0.443–7.658	0.401
DTA mutations (yes vs no)	2.500	0.935–6.684	0.068	2.287	0.443–11.799	0.323
Mutation of methylation (yes vs no)	2.400	0.943–6.107	0.066	1.413	0.278–7.193	0.677
CMV (yes vs no)	0.484	0.209–1.116	0.089	0.460	0.163–1.302	0.144
EBV (yes vs no)	0.394	0.161–0.963	0.041	0.445	0.147–1.353	0.154
Fungal (yes vs no)	0.180	0.031–1.033	0.054	0.194	0.018–2.101	0.178

CH mutations (yes vs no)	3.391	1.005–11.439	0.049	2.447	0.682–8.780	0.170
CMV (yes vs no)	0.235	0.078–0.706	0.010	0.288	0.092–0.900	0.032
Fungal (yes vs no)	0.129	0.011–1.514	0.103	0.269	0.017–3.104	0.269
, ≥
Mutated DNMT3A (yes vs no)^a	6.500	1.127–37.484	0.036	25.443	1.072–603.681	0.045
Disease status at transplantation (non-CR vs CR)	0.458	0.044–4.820	0.516
Platelets (×10/L)	1.011	0.998–1.025	0.103	1.007	0.994–1.019	0.294
Fungal (yes vs no)	0.182	0.030–1.102	0.064	0.046	0.003–0.738	0.030
^a Patients with DNMT3A mutation but no TET2 or ASXL1 mutations; ^b patients without DTA mutations; ^c patients with TET2 or ASXL1 mutations but no DNMT3A mutation. OR – odds ratio; haplo-HSCT – haploidentical hematopoietic stem cell transplantation; CR – complete response; CH mutations – clonal hematopoiesis-associated mutation; DTA mutations – mutated DNMT3A, TET2, or ASXL1; CMV – cytomegalovirus; EBV – Epstein-Barr Virus.

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Clonal Hematopoiesis-Associated Gene Mutations Affect Acute Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation in AML Patients

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