Clonal Hematopoiesis-Associated Gene Mutations Affect Acute Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation in AML Patients

Xiaoxuan Wei; Sai Huang; Zhenyang Gu; Jing Liu; Meng Li; Xiangshu Jin; Jian Bo; Fei Li; Yu Jing; Xiaoning Gao; Liping Dou; Daihong Liu; Chunji Gao

doi:10.12659/AOT.943688

02 July 2024 : Original article

Clonal Hematopoiesis-Associated Gene Mutations Affect Acute Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation in AML Patients

Xiaoxuan Wei^12ABCDEF, Sai Huang^1ABF, Zhenyang Gu^1ADEF, Jing Liu^1ADEF, Meng Li^1AF, Xiangshu Jin^1AF, Jian Bo^1AF, Fei Li^1A, Yu Jing^1A, Xiaoning Gao^1A, Liping Dou^1AB, Daihong Liu^1A, Chunji Gao^1ADEF*

DOI: 10.12659/AOT.943688

Ann Transplant 2024; 29:e943688

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Table 7 Univariate and multivariate analyses for OS and PFS in 196 patients receiving allo-HSCT.

	Univariate analysis			Multivariate analysis
	HR	95% CI	P	HR	95% CI	P

Age	1.007	0.987–1.027	0.481
Donor type (haploidentical vs matched)	1.605	0.970–2.656	0.065	1.361	0.809–2.291	0.246
Disease status at transplantation
PR vs CR	2.501	0.901–6.940	0.078	2.293	0.804–6.544	0.121
NR vs CR	3.646	1.457–9.121	0.006	3.444	1.366–8.685	0.009
Rel vs CR	1.323	0.480–3.644	0.589	1.224	0.443–3.383	0.697
CH mutations (yes vs no)	1.304	0.821–2.071	0.260
DTA mutations (yes vs no)	0.973	0.571–1.660	0.921
Mutated DNMT3A (yes vs no)	0.713	0.327–1.555	0.395
aGVHD (yes vs no)	1.050	0.656–1.680	0.838
cGVHD (yes vs no)	0.770	0.442–1.342	0.356
TA-TMA (yes vs no)	3.050	1.313–7.083	0.010	3.000	1.277–7.049	0.012

Age	1.006	0.988–1.024	0.513
Donor type (haploidentical vs matched)	1.550	0.990–2.427	0.056	1.333	0.837–2.123	0.226
Disease status at transplantation
PR vs CR	1.435	0.450–4.578	0.541	1.416	0.434–4.616	0.564
NR vs CR	3.570	1.301–9.793	0.013	2.626	0.935–7.380	0.067
Rel vs CR	2.182	1.005–4.739	0.039	2.490	1.134–5.467	0.023
CH mutations (yes vs no)	1.494	0.987–2.261	0.058	1.482	0.963–2.281	0.074
DTA mutations (yes vs no)	1.123	0.711–1.772	0.619
Mutated DNMT3A (yes vs no)	0.898	0.478–1.688	0.738
aGVHD (yes vs no)	1.104	0.721–1.689	0.649
cGVHD (yes vs no)	0.698	0.42–1.158	0.164
TA-TMA (yes vs no)	2.803	1.287–6.101	0.009	2.703	1.230–5.940	0.013
HR – hazard ratio; OS – overall survival; LFS – leukemia-free survival; CR – complete remission; PR – partial response; NR – no response; CH mutations – clonal hematopoiesis-associated mutation; DTA mutations, – mutated DNMT3A, TET2, or ASXL1; aGVHD – acute graft versus host disease; cGVHD – chronic graft versus host disease; TA-TMA – transplantation-associated thrombotic microangiopathy.

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Clonal Hematopoiesis-Associated Gene Mutations Affect Acute Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation in AML Patients

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