Early Post-Transplant Serum Ferritin Levels as Predictive Biomarkers for Severe Acute Graft-Versus-Host Disease in Pediatric Umbilical Cord Blood Transplantation for Acute Leukemia

Zhiqi Zhang; Bohan Li; Lu Liu; Ruolan Xiong; Senlin Zhang; Minyuan Liu; Zihao Xia; Shuran Wang; Jie Li; Shaoyan Hu

doi:10.12659/AOT.944156

27 August 2024 : Original article

Early Post-Transplant Serum Ferritin Levels as Predictive Biomarkers for Severe Acute Graft-Versus-Host Disease in Pediatric Umbilical Cord Blood Transplantation for Acute Leukemia

Zhiqi Zhang^1ABCDEF, Bohan Li^1ABCDEF, Lu Liu^2ABCDEF, Ruolan Xiong^1BCDE, Senlin Zhang^3ABC, Minyuan Liu^1ABC, Zihao Xia^1BCE, Shuran Wang^1BCE, Jie Li^1CDEFG, Shaoyan Hu^14ABCDEFG*

DOI: 10.12659/AOT.944156

Ann Transplant 2024; 29:e944156

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Introduction Material and Methods Results Discussion Conclusions References

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Table 2 Risk factors for the occurrence of III–IV acute graft-versus-host disease in pediatric patients undergoing allogeneic hematopoietic stem-cell transplantation.

Risk factors	Univariate			Multivariate
Risk factors	HR	95% CI	P value	HR	95% CI	P value
Age	0.99	0.89–1.12	0.920
Sex female vs male	1.27	0.51–3.17	0.600
Disease (AL type)	1.94	0.80–4.73	0.140
HLA matching	0.46	0.18–1.14	0.093*	0.45	0.18–1.17	0.100
ABO matching	1.27	0.46–3.51	0.640
Disease status at transplant
CR1	1.65	0.61–4.48	0.330
CR2	0.51	0.12–2.17	0.360
PR	1.19	0.37–3.84	0.770
NR	Reference
Conditioning intensity	0.32	0.13–0.81	0.017*	0.34	0.13–0.89	0.027
ATG	0.50	0.12–2.04	0.330
Conditioning drug dose
Bu	0.92	0.69–1.23	0.560
CTX	0.98	0.95–1.02	0.340
Neutrophil engraftment time	1.00	0.90–1.12	0.950
Platelet engraftment time	1.01	0.97–1.05	0.610
Total infused cell count
MNC	1.03	0.85–1.24	0.800
CD34+	1.01	0.81–1.27	0.900
SF level within 2 weeks post-transplant	3.98	1.16–13.60	0.028*	3.61	1.09–11.97	0.036
SF level within 2 weeks pretransplant	1.97	0.66–5.89	0.220
AL – acute leukemia; ATG – anti-thymocyte globulin; Bu – busulfan; CI – confidence interval; CR – complete response; CTX – cyclophosphamide; HR – hazard ratio; MNC – mononuclear cells; NR – no response; PR – partial response; SF – serum ferritin.

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Early Post-Transplant Serum Ferritin Levels as Predictive Biomarkers for Severe Acute Graft-Versus-Host Disease in Pediatric Umbilical Cord Blood Transplantation for Acute Leukemia

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