03 December 2024 : Original article
Hepatopulmonary Syndrome and Liver Transplantation: Impact on Survival and Postoperative Complications
Yin Lai ABCDEF 1,2, Hao-Chien Hung BCD 1,2, Jin-Chiao Lee BCD 1,2, Yu-Chao Wang CDE 1,2, Chih-Hsien Cheng CDE 1,2, Tsung-Han Wu BCD 1,2, Ting-Jung Wu BCD 1,2, Hong-Shiue Chou CDE 1,2, Kun-Ming Chan DEF 1,2, Wei-Chen Lee DEF 1,2, Chen-Fang Lee ACDEF 1,2*DOI: 10.12659/AOT.945297
Ann Transplant 2024; 29:e945297
Table 1 Comparisons of baseline demographics of hepatopulmonary syndrome (HPS) group and non-HPS group.
| General Information | Non-HPS, n=77 | HPS, n=104 | P value |
|---|---|---|---|
| Age (mean±SD) | 54.62±9.9 | 53.73±8.1 | 0.224 |
| Sex | 0.482 | ||
| Male | 61 (79.2%) | 77 (74.0%) | |
| Female | 16 (20.8%) | 27 (26.0%) | |
| Viral hepatitis | 0.023 | ||
| No | 21 (27.3%) | 38 (36.5%) | |
| HBV | 45 (58.4%) | 40 (38.5%) | |
| HCV | 11 (14.3%) | 21 (20.2%) | |
| HBV and HCV | 0 | 5 (4.8%) | |
| Child-Pugh class | <0.0001 | ||
| A | 34 (44.2%) | 17 (16.3%) | |
| B | 19 (24.7%) | 47 (45.2%) | |
| C | 24 (31.1%) | 40 (38.5%) | |
| MELD at transplant | |||
| Mean±SD | 15.14±9.6 | 16.98±7.1 | 0.003 |
| <20 | 58 (75.3%) | 77 (74.0%) | 0.865 |
| ≥20 | 19 (24.7%) | 27 (26.0%) | |
| GRWR (%) | 0.97±0.3 | 0.96±0.2 | 0.360 |
| Indication for liver transplantion | <0.0001 | ||
| Liver cirrhosis | 18 (23.4%) | 58 (55.8%) | |
| HCC | 5 (6.5%) | 0 (0.0%) | |
| Liver cirrhosis and HCC | 36 (46.8%) | 36 (34.6%) | |
| Acute flare of Hepatitis | 11 (14.3%) | 3 (2.9%) | |
| Other | 7 (9.1%) | 7 (6.7%) | |
| Pre-LT PaO (mmHg) | 0.444 | ||
| Mild ≥80 | 61 (79.2%) | 72 (69.3%) | |
| Moderate 60–79 | 14 (18.2%) | 26 (25.0%) | |
| Severe 50–59 | 1 (1.3%) | 2 (1.9%) | |
| Very severe <50 | 1 (1.3%) | 4 (3.8%) | |
| Bubble test grade | <0.0001 | ||
| Grade 1 | 1 (1.3%) | 46 (44.2%) | |
| Grade 2 | 0 | 27 (26.0%) | |
| Grade 3 | 0 | 17 (16.3%) | |
| Grade 4 | 0 | 12 (11.5%) | |
| Grade 5 | 0 | 2 (2.0%) | |
| Graft choice | 0.470 | ||
| Right lobe | 75 (97.4%) | 98 (94.2%) | |
| Left lobe | 2 (2.6%) | 6 (5.8%) | |
| ABO incompatible | 6 (7.8%) | 19 (18.3%) | 0.051 |
| HPS – hepatopulmonary syndrome; HCC – hepatocellular carcinoma; HBV – hepatitis B virus; HCV – hepatitis C virus; LT – liver transplantation; MELD – model of end-stage liver disease; GRWR – graft-to-recipient weight ratio. | |||