Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

15 January 2004 : Case report  

Cytokine Secretion During in Vitro Cellular Interaction with Titanium Alloy and Nitrided Surface Layers Produced Under Glow Discharge Conditions

B Cukrowska, A Sowinska, A Zajaczkowska, J R Sobiecki, T Wierzchon, E Czarnowska

Ann Transplant 2004; 9(1A): 76-78 :: ID: 15640

Abstract

Objectives: Nitrided surface layers improve wear and corrosion resistance of titanium alloys and demonstrate good biocompatibility. Their influence on the cytokines that play a role in inflammatory and repair reactions in bones has not been studied yet. This study tested whether nitrided surface layers produced under glow discharge conditions could protect against secretion of inflammatory mediators that are known to be induced by titanium alloys.
Methods: Production of pro-inflammatory cytokines such as TNF-α, IL-1β and IL-6 was measured in experimental cultures of human fibroblasts received from three donors and cultivated on Ti6Al4V alloy and titanium alloy samples with a TiN+Ti2N+αTi(N) type layer.
Results and conclusions: Analyses of the released cytokines showed that TiN layers induce secretion of inflammatory mediators to an even
lesser extent than titanium alloy, which confirms the value of nitrided surface layers in medical applications.

Keywords: Nitrided Titanium Alloy, Cytokines

Add Comment 0 Comments

In Press

Original article  

Engraftment Syndrome in Autologous Hematopoietic Stem Cell Transplant Patients: Incidence, Associated Risk ...

Ann Transplant In Press; DOI: 10.12659/AOT.944043  

Original article  

Comparative Study of Acute Kidney Injury in Liver Transplantation: Donation after Circulatory Death versus ...

Ann Transplant In Press; DOI: 10.12659/AOT.944077  

Original article  

Abnormal Liver Biopsies of Donor Grafts in Pediatric Liver Transplantation: How Do They Fare?

Ann Transplant In Press; DOI: 10.12659/AOT.944245  

Original article  

Kidney After Lung Transplants or Combined Kidney–Lung Transplantation: A Single-Center Retrospective Cohort...

Ann Transplant In Press; DOI: 10.12659/AOT.944049  

Most Viewed Current Articles

05 Apr 2022 : Original article   12,404

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

22 Nov 2022 : Original article   9,258

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

12 Jan 2022 : Original article   8,843

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

15 Mar 2022 : Case report   6,648

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358