Ann Transplant 2004; 9(1A): 119-120 :: ID: 496222
Restoration of bone and cartilage tissue defects has been a clinical challenge of contemporary orthopedic surgery for more than hundred years. Today’s methods of skeletal defect reconstruction are based on the use of bone grafts and on the technique of distraction osteogenesis. The third approach, the use of growth and differentiation factors has been shown to be effective in preclinical studies as well as in two large multi-center clinical trials on
delayed union and open fractures...
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