Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

14 March 2003

"One Size Fits All": Immunosuppression in Cardiac Transplantation

David A Baran, Ira D Galin

Ann Transplant 2003; 8(1): 7-9 :: ID: 496870

Abstract

Approximately 20 years have passed since the introduction of cyclosporine-based triple therapy for heart transplant recipients. The major thrust of research has been the “middle-drug” between cyclosporine and steroids, and recent efforts have been directed towards newer antibody preparations to induce rapid immunosuppression post-transplant. However, little effort has been paid to attempts to reduce and tailor immunosuppression to specific patients. This paper describes previous work on the individualized dosing of tacrolimus, including patients who are maintained on monotherapy after heart transplantation with tacrolimus alone. The authors conclude that future efforts need to be directed towards individualizing immunosuppression rather than adopting “one-size-fits-all” insitutional protocols.

Keywords: Immunosuppression, Heart Transplant, Tacrolimus, Tailored Therapy

Add Comment 0 Comments

In Press

Original article  

Engraftment Syndrome in Autologous Hematopoietic Stem Cell Transplant Patients: Incidence, Associated Risk ...

Ann Transplant In Press; DOI: 10.12659/AOT.944043  

Original article  

Comparative Study of Acute Kidney Injury in Liver Transplantation: Donation after Circulatory Death versus ...

Ann Transplant In Press; DOI: 10.12659/AOT.944077  

Original article  

Abnormal Liver Biopsies of Donor Grafts in Pediatric Liver Transplantation: How Do They Fare?

Ann Transplant In Press; DOI: 10.12659/AOT.944245  

Original article  

Kidney After Lung Transplants or Combined Kidney–Lung Transplantation: A Single-Center Retrospective Cohort...

Ann Transplant In Press; DOI: 10.12659/AOT.944049  

Most Viewed Current Articles

05 Apr 2022 : Original article   12,433

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

22 Nov 2022 : Original article   9,299

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

12 Jan 2022 : Original article   8,875

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

15 Mar 2022 : Case report   6,675

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358