Reported here is a case of mediastinitis caused by candida albicansand Staphylococcusaureus followinga heart transplantation that was successfully treated with caspofungin, antibiotics and mediastinal lavage. A review of the literature revealed that Candida albicans as a cause of mediastinitis has been rarely described. In the few existing reports, evolution was generally fatal, especially in immunocompromised patients, despite treatment with antifungal drugs and antibiotics.

Keywords: Heart Transplantation, fungal infection, mediastinitis