Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

08 December 2000

Leukocytes and Endothelium Interactionas Rate Limiting Step in the Infammatory Response and a Key Factor in the Ischemia-Reperfusion Injury

Piotr Fiedor

Ann Transplant 2000; 5(4): 5-11 :: ID: 497544

Abstract

Leukocyte- endothelium interactions playa key role in regulation of the inflammatory response. leukocytes migration and ischaemia-reperfusion injury. These adhesive reactions controlling the circulation of leukocytes. are key parts of immune surveillance arising from extravasation of neutrophils. and migration into tissue to eliminate invading microorganism. They also play important role in the generation of ischaemic-reperfusion injury of different organs including brain. Plasma levels of soluble adhesion molecules may be a diagnostic marker of the systemic endothelial injury. It is likely that the next few years bring new therapies to control leukocyte-endothelial interaction by directly inhibiting the adhesion molecules or by modulating their expression.

Keywords: leukocyte, Ischemia, molecules expression, Endothelium, Reperfusion Injury

Add Comment 0 Comments

434 1

In Press

17 May 2023 : Original article  

Results of Liver Retransplantation After Rescue Hepatectomy: A Single-Center Study

Ann Transplant In Press; DOI: 10.12659/AOT.939557  

10 May 2023 : Case report  

Outcomes from a Single Transplant Center of 5 Pediatric Cases of Domino Liver Transplantation from Live Don...

Ann Transplant In Press; DOI: 10.12659/AOT.939893  

Most Viewed Current Articles

24 Aug 2021 : Review article  

Normothermic Machine Perfusion (NMP) of the Liver – Current Status and Future Perspectives

DOI :10.12659/AOT.931664

Ann Transplant 2021; 26:e931664

26 Jan 2022 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

29 Dec 2021 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358