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28 September 2010

Potential role of immunoablation and hematopoietic cell transplantation in the treatment of early diabetes type 1

Emilian Snarski, Alicja Milczarczyk, Edward Franek, Wieslaw Wiktor Jedrzejczak

Ann Transplant 2010; 15(3): 75-79 :: ID: 881175

Abstract

Immunoablation with autologous hematopoietic cell transplantation has shown some effectiveness in the treatment of autoimmune diseases as diverse as aplastic anemia, systemic lupus erythematosus, multiple sclerosis and Crohn’s disease. It has been recently shown that this treatment might prevent or delay development of diabetes type 1. The majority of more than 30 patients with early diabetes type 1 who underwent immunoablation and hematopoietic cell transplantation in various centers in the world achieved durable remission of diabetes and independence of exogenous insulin. This review summarizes advantages and risks of this treatment of early diabetes type 1.

Keywords: Bone Marrow Transplantation, diabetes mellitus type 1, immunoablation

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358