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05 March 2024: Original Paper

No Prognostic Impact of Graft-to-Recipient Weight Ratio on Hepatocellular Carcinoma Recurrence Following Living Donor Liver Transplantation

Geunhyeok Yang 1BCDEF , Shin Hwang 2ABCDEF* , Chul-Soo Ahn 2BCDE , Deok-Bog Moon 2BCDE , Tae-Yong Ha 2ABCDE , Gi-Won Song 2BCDE , Dong-Hwan Jung 2BCDE , Gil-Chun Park 2BCDE , Young-In Yoon 2BCDE , Woo-Hyoung Kang 2BCDE , Sun-Hyung Joo 1BCDE , Sung-Gyu Lee 2BCDE

DOI: 10.12659/AOT.942767

Ann Transplant 2024; 29:e942767

Table 1 Clinico-pathological features of the living donor liver transplantation recipients according to the graft-to-recipient weight ratio (GRWR).

Parameters/groupsAllGRWR <0.8%GRWR 0.8–0.99%GRWR 1.0–1.19%GRWR ≥1.2%p-value
Patients, n (%)85654 (6.3%)272 (31.8%)274 (32.0%)256 (29.9%)
Age (years), mean±SD53.8±6.251.9±7.453.0±6.254.0±6.054.9±6.10.001
Background liver disease, n0.039
MELD score (median)1010109110.055
AFP (median, ng/mL)12.710.913.11311.20.923
DCP (median, AU/L)27282530270.272
Explant pathology
 Tumor number (median)111110.176
 Maximal tumor diameter (median, cm)222.1220.083
 Total tumor volume (median, mL)11.21.915.611.59.20.559
 ADV score (median, log10)
 Macrovascular invasion, n (%)40 (4.7%)4 (7.4%)10 (3.7%)11 (4.0%)15 (5.9%)0.422
 Microvascular invasion, n (%)145 (16.9%)12 (22.2%)47 (17.3%)47 (17.2%)39 (15.2%)0.556
Within Milan criteria602 (70.3%)41 (75.9%)184 (67.6%)191 (69.7%)186 (72.7%)0.482
ABO-incompatible LT, n (%)136 (15.9%)16 (29.6%)40 (14.7%)35 (12.8%)45 (17.6%)0.015
Graft-to-recipient weight ratio (median)1.060.750.911.091.35
Graft type, n (%)0.036
 Right liver graft842 (98.4%)51 (94.4%)265 (97.4%)270 (98.5%)256 (100%)
 Left liver graft14 (1.6%)3 (5.6%)7 (2.6%)4 (1.5%)0 (0%)
SD – standard deviation; HBV – hepatitis B virus; HCV – hepatitis C virus; ALD – alcoholic liver disease; MELD – model for end-stage liver disease; AFP – α-fetoprotein; DCP – des-γ-carboxy prothrombin; ADV – product of AFP and DCP concentrations and tumor volume; LT – liver transplantation.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358