05 March 2024 : Original article
No Prognostic Impact of Graft-to-Recipient Weight Ratio on Hepatocellular Carcinoma Recurrence Following Living Donor Liver Transplantation
Geunhyeok Yang
1BCDEF, Shin Hwang 2ABCDEF*, Chul-Soo Ahn 2BCDE, Deok-Bog Moon 2BCDE, Tae-Yong Ha 2ABCDE, Gi-Won Song 2BCDE, Dong-Hwan Jung 2BCDE, Gil-Chun Park 2BCDE, Young-In Yoon 2BCDE, Woo-Hyoung Kang 2BCDE, Sun-Hyung Joo 1BCDE, Sung-Gyu Lee 2BCDE
DOI: 10.12659/AOT.942767
Ann Transplant 2024; 29:e942767
Table 1 Clinico-pathological features of the living donor liver transplantation recipients according to the graft-to-recipient weight ratio (GRWR).
| Parameters/groups | All | GRWR <0.8% | GRWR 0.8–0.99% | GRWR 1.0–1.19% | GRWR ≥1.2% | p-value |
|---|---|---|---|---|---|---|
| Patients, n (%) | 856 | 54 (6.3%) | 272 (31.8%) | 274 (32.0%) | 256 (29.9%) | |
| Age (years), mean±SD | 53.8±6.2 | 51.9±7.4 | 53.0±6.2 | 54.0±6.0 | 54.9±6.1 | 0.001 |
| Background liver disease, n | 0.039 | |||||
| HBV | 743 | 49 | 247 | 235 | 212 | |
| HCV | 63 | 1 | 13 | 24 | 25 | |
| ALD | 33 | 3 | 11 | 8 | 11 | |
| Others | 17 | 1 | 1 | 7 | 8 | |
| MELD score (median) | 10 | 10 | 10 | 9 | 11 | 0.055 |
| AFP (median, ng/mL) | 12.7 | 10.9 | 13.1 | 13 | 11.2 | 0.923 |
| DCP (median, AU/L) | 27 | 28 | 25 | 30 | 27 | 0.272 |
| Explant pathology | ||||||
| Tumor number (median) | 1 | 1 | 1 | 1 | 1 | 0.176 |
| Maximal tumor diameter (median, cm) | 2 | 2 | 2.1 | 2 | 2 | 0.083 |
| Total tumor volume (median, mL) | 11.2 | 1.9 | 15.6 | 11.5 | 9.2 | 0.559 |
| ADV score (median, log10) | 3.7 | 3.2 | 3.8 | 3.6 | 3.5 | 0.358 |
| Macrovascular invasion, n (%) | 40 (4.7%) | 4 (7.4%) | 10 (3.7%) | 11 (4.0%) | 15 (5.9%) | 0.422 |
| Microvascular invasion, n (%) | 145 (16.9%) | 12 (22.2%) | 47 (17.3%) | 47 (17.2%) | 39 (15.2%) | 0.556 |
| Within Milan criteria | 602 (70.3%) | 41 (75.9%) | 184 (67.6%) | 191 (69.7%) | 186 (72.7%) | 0.482 |
| ABO-incompatible LT, n (%) | 136 (15.9%) | 16 (29.6%) | 40 (14.7%) | 35 (12.8%) | 45 (17.6%) | 0.015 |
| Graft-to-recipient weight ratio (median) | 1.06 | 0.75 | 0.91 | 1.09 | 1.35 | <0.001 |
| Graft type, n (%) | 0.036 | |||||
| Right liver graft | 842 (98.4%) | 51 (94.4%) | 265 (97.4%) | 270 (98.5%) | 256 (100%) | |
| Left liver graft | 14 (1.6%) | 3 (5.6%) | 7 (2.6%) | 4 (1.5%) | 0 (0%) | |
| SD – standard deviation; HBV – hepatitis B virus; HCV – hepatitis C virus; ALD – alcoholic liver disease; MELD – model for end-stage liver disease; AFP – α-fetoprotein; DCP – des-γ-carboxy prothrombin; ADV – product of AFP and DCP concentrations and tumor volume; LT – liver transplantation. | ||||||