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The New Approaches to Preservation of Graft Cell Integrity in Preservation for Transplantation

Magdalena Gewartowska, Waldemar L. Olszewski

Ann Transplant 2005; 10(4): 6-10

ID: 498360

Published:


Restoration of cell plasma membrane integrity after injury is essential for the survival of animal cells. In case of graft preservation or during chemotherapy in cancer, cell membrane integrity and the process of its repair are disrupted. Cytoprotective substances are important in such cases, as well as in other diseases, for example in myocardial infarction, acute insults and in chronic neurodegenerative diseases. Hyperosmolarity is a condition in which cell membrane stabilitymay be damaged in vivo but preserved in the in vitro conditions. Hypertonicity causes water leavingfrom cells by osmosis, decreasing cell volume and increasing of intracellular ionic strength. High intracellular ionic strength perturbs cellular function by decreasing the rates of biochemical reaction. We review the new experimentally studied cytoprotective substances and their application in cell membrane protection. Moreover, we present our data on the effects of hyperosmolarity and its protective effect on cell internal structure.

Keywords: Cell Membrane, Cytoprotection, Hyperosmolality, cytoprotective drugs



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