Is Kidney Donor Profile Index (KDPI) Valid for Hepatitis C Aviremic Kidneys?

ABSTRACT: The Kidney Donor Risk Index (KDRI) and Kidney Donor Profile Index (KDPI) assist clinicians with the selection of deceased donor kidneys. This scoring system is based on 10 donor factors including Hepatitis C virus (HCV) status from serological or NAT testing. The donor HCV status (i.e., having either a positive hepatitis C antibody (Ab) or nucleic acid testing (NAT) result) increases the hazard ratio for graft failure by 1.27 and the KDPI by approximately 20%. Whether this increase in KDPI is a true reflection of graft quality for HCV seropositive but not viremic donors is unknown. Further investigations are needed to maximize the use of these organs.

Keywords: Hepatitis C Antibodies, Tissue and Organ Procurement, Tissue Donors

References

1. Israni AK, Salkowski N, Gustafson S, New national allocation policy for deceased donor kidneys in the United States and possible effect on patient outcomes: J Am Soc Nephrol, 2014; 25(8); 1842-48, pmid: 24833128

2. Rao PS, Schaubel DE, Guidinger MK, A comprehensive risk quantification score for deceased donor kidneys: The kidney donor risk index: Transplantation, 2009; 88(2); 231-36, pmid: 19623019

3. Abbott KC, Bucci JR, Matsumoto CS, Hepatitis C and renal transplantation in the era of modern immunosuppression: J Am Soc Nephrol, 2003; 14(11); 2908-18, pmid: 14569101

4. , UNet System Notice – Upcoming Waitlist and and DonorNet changes will reflect policy changes regarding infectious diseases screening [Internet]: UNOS System Notices - General Notice, 2017 [cited 16 March 2017]. Available from:https://portal.unos.org/ViewSystemNotice.aspx?id=3074